Breast nonmalignant
Inflammatory
Foreign body reaction


Topic Completed: 1 April 2010

Revised: 3 September 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Breast foreign body [title] reaction

Hind Warzecha, M.D.
Page views in 2018: 2,975
Page views in 2019 to date: 2,643
Cite this page: Warzecha H. Foreign body reaction. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastforeignbodyreaction.html. Accessed October 22nd, 2019.
Definition / general
  • Foreign body giant cell inflammation that usually is localized and occurs 1 - 2 weeks after trauma, surgery or radiation
Terminology
Clinical features
  • Clinically resembles carcinoma due to skin retraction
Case reports
Due to injections:
Gross description
  • Localized to subcutaneous tissue
  • May be nodular, fibrotic, orange brown (due to hemosiderin)
  • Up to 1 cm
Microscopic (histologic) description
  • Not encapsulated
  • Fibrosis, foreign body giant cells, chronic inflammatory cells, fat necrosis, calcification, cholesterol clefts (needle-like empty spaces, due to substances dissolved during processing), hemosiderin
  • May see a foreign body
Microscopic (histologic) images


Contributed by Dr. Saroona Haroon, The Aga Khan University Hospital (Pakistan)

Cholesterol granuloma in 56 year old woman with 4 month history of hard immobile mass of left breast; no history of pus or blood discharge



Images hosted on other servers:

Fibrosis and multinucleated giant cells

Small blood vessel proliferation and giant cells

Collagen plug inside biopsy cavity

Asteroid body

Granulation tissue

Videos


Foreign body reaction
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