Breast nonmalignant
Foreign body reaction

Topic Completed: 1 April 2010

Revised: 30 May 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Breast foreign body [title] reaction

Hind Warzecha, M.D.
Page views in 2018: 2,975
Page views in 2019 to date: 2,037
Cite this page: Nassar H Foreign body reaction. website. Accessed August 19th, 2019.
Definition / general
  • Foreign body giant cell inflammation that usually is localized and occurs 1 - 2 weeks after trauma, surgery or radiation
Clinical features
  • Clinically resembles carcinoma due to skin retraction
Case reports
Due to injections:
Gross description
  • Localized to subcutaneous tissue
  • May be nodular, fibrotic, orange brown (due to hemosiderin)
  • Up to 1 cm
Microscopic (histologic) description
  • Not encapsulated
  • Fibrosis, foreign body giant cells, chronic inflammatory cells, fat necrosis, calcification, cholesterol clefts (needle-like empty spaces, due to substances dissolved during processing), hemosiderin
  • May see a foreign body
Microscopic (histologic) images

Images hosted on other servers:

Fibrosis and multinucleated giant cells

Small blood vessel proliferation and giant cells

Collagen plug inside biopsy cavity

Asteroid body

Granulation tissue

Contributed by Dr. Saroona Haroon, The Aga Khan University Hospital (Pakistan):

Cholesterol granuloma in 56 year old woman with 4 month history of hard immobile mass of left breast; no history of pus or blood discharge


Foreign body reaction
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