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Breast-nonmalignant

Inflammatory / infectious lesions

Giant cell arteritis

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 27 September 2012, UPDATE IN PROGRESS

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Vascular disorder that may have systemic manifestations, but no temporal artery involvement (Hum Path 1987;18:1186)

 

Terminology

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Epidemiology

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Usually post-menopausal women with firm mass that mimics carcinoma

 

Sites

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Etiology

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Clinical features

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● Nodules or pain in the breast, with or without tenderness

● Associated with significant constitutional symptoms that resemble polymyalgia rheumatica (Breast Cancer 2009 May 21 [Epub ahead of print])

 

Prognostic factors

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Case reports

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● 56 year old woman with breast tenderness but no systemic complaints (Med Princ Pract 2004;13:234)

● 74 year old woman with associated infiltrating ductal carcinoma (Onkologie 2008;31:685)

● Bilateral involvement (Am J Med Sci 2008;335:489)

 

Treatment

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● Possibly prednisone therapy

 

Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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● Involvement of small and medium sized arteries with transmural and perivascular infiltrate of lymphocytes, histiocytes and giant cells

● Elastic stain shows fragmentation of elastic fibers in vessel wall

 

Micro images

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Intramammary arterial lumen is mostly                       Transmural necrotizing inflammation of medium

obliterated by subintimal and mural                              sized mammary vessels, with elastic stain

inflammation, including giant cells (arrows)               showing partial destruction of elastic layer

 

Drawings

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Virtual Slides

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Videos

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Cytology description

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Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Polyarteritis nodosa: transmural necrotizing vasculitis without giant cells; often prominent eosinophils, fibrinoid necrosis

Wegener’s granulomatosis: acute and chronic inflammation of breast parenchyma and fat; may resemble an abscess; vessels in necrotic areas and in surrounding breast exhibit fibrinoid necrosis; granulomatous foci in blood vessels and at peripheral of breast infarcts

 

Additional references

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End of Breast-nonmalignant > Inflammatory / infectious lesions > Giant cell arteritis of breast

 

 

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