Home Chapter Home Jobs Conferences Fellowships Books
Advertisement
Breast-nonmalignant
Inflammatory / infectious lesions
Giant cell arteritis
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 27 September 2012, UPDATE IN PROGRESS
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
=========================================================================
● Vascular disorder that may have systemic manifestations, but no temporal artery involvement (Hum Path 1987;18:1186)
Terminology
=========================================================================
●
Epidemiology
=========================================================================
● Usually post-menopausal women with firm mass that mimics carcinoma
Sites
=========================================================================
●
Etiology
=========================================================================
●
Clinical features
=========================================================================
● Nodules or pain in the breast, with or without tenderness
● Associated with significant constitutional symptoms that resemble polymyalgia rheumatica (Breast Cancer 2009 May 21 [Epub ahead of print])
Prognostic factors
=========================================================================
●
Case reports
=========================================================================
● 56 year old woman with breast tenderness but no systemic complaints (Med Princ Pract 2004;13:234)
● 74 year old woman with associated infiltrating ductal carcinoma (Onkologie 2008;31:685)
● Bilateral involvement (Am J Med Sci 2008;335:489)
Treatment
=========================================================================
● Possibly prednisone therapy
Clinical images
=========================================================================
●
Gross description (Macroscopy)
=========================================================================
●
Gross images
=========================================================================
Micro description (Histopathology)
=========================================================================
● Involvement of small and medium sized arteries with transmural and perivascular infiltrate of lymphocytes, histiocytes and giant cells
● Elastic stain shows fragmentation of elastic fibers in vessel wall
Micro images
=========================================================================
Intramammary arterial lumen is mostly Transmural necrotizing inflammation of medium
obliterated by subintimal and mural sized mammary vessels, with elastic stain
inflammation, including giant cells (arrows) showing partial destruction of elastic layer
Drawings
=========================================================================
Virtual Slides
=========================================================================
Videos
=========================================================================
Cytology description
=========================================================================
●
Cytology images
=========================================================================
●
Positive stains
=========================================================================
●
Negative stains
=========================================================================
●
Electron microscopy descriptions
=========================================================================
●
Electron microscopy images
=========================================================================
Molecular / cytogenetics description
=========================================================================
●
Molecular / cytogenetics images
=========================================================================
Differential Diagnosis
=========================================================================
● Polyarteritis nodosa: transmural necrotizing vasculitis without giant cells; often prominent eosinophils, fibrinoid necrosis
● Wegener’s granulomatosis: acute and chronic inflammation of breast parenchyma and fat; may resemble an abscess; vessels in necrotic areas and in surrounding breast exhibit fibrinoid necrosis; granulomatous foci in blood vessels and at peripheral of breast infarcts
Additional references
=========================================================================
●
End of Breast-nonmalignant > Inflammatory / infectious lesions > Giant cell arteritis of breast
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).