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Breast-nonmalignant
Benign tumors / changes
Gynecomastia-like changes of female breast
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 7 October 2012, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Increased ducts and prominent stroma, histologically identical to gynecomastia of the male breast
Terminology
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● Also called gynecomastoid hyperplasia
Epidemiology
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● 0.15% of female breast lesions (Arch Pathol Lab Med 2001;125:506, Arch Pathol Lab Med 2000;124:844)
Etiology
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Clinical features
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● Mean age 32 years, patients present with palpable mass associated with fibrocystic changes in adjacent breast
Prognostic factors
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Case reports
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Treatment
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Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Poorly circumscribed areas of ductal hyperplasia with periductal stromal fibrosis or edema and slight lymphocytic infiltrate
● Involves one low power field or entire core fragment of at least 1 cm, without terminal duct-lobular units present (same as male gynecomastia)
● No associated mammary hamartomatous changes, no areas of juvenile hyperplasia, no juvenile fibroadenoma
Micro images
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Proliferation of ducts with periductal fibrosis but without lobules
Virtual Slides
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Videos
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Cytology description
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Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Hamartoma: sharply circumscribed, has lobules, variable smooth muscle or cartilage, no periductal stromal changes
● Pubertal macromastia: young patients, massive involvement
Additional references
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End of Breast-nonmalignant > Benign tumors / changes > Gynecomastia-like changes of female breast
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