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Breast-nonmalignant

Benign tumors / changes

Gynecomastia-like changes of female breast

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 7 October 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Increased ducts and prominent stroma, histologically identical to gynecomastia of the male breast 

 

Terminology

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● Also called gynecomastoid hyperplasia

 

Epidemiology

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● 0.15% of female breast lesions (Arch Pathol Lab Med 2001;125:506, Arch Pathol Lab Med 2000;124:844)

 

Etiology

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Clinical features

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● Mean age 32 years, patients present with palpable mass associated with fibrocystic changes in adjacent breast

 

Prognostic factors

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Case reports

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Treatment

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Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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● Poorly circumscribed areas of ductal hyperplasia with periductal stromal fibrosis or edema and slight lymphocytic infiltrate

● Involves one low power field or entire core fragment of at least 1 cm, without terminal duct-lobular units present (same as male gynecomastia)

● No associated mammary hamartomatous changes, no areas of juvenile hyperplasia, no juvenile fibroadenoma

 

Micro images

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Proliferation of ducts with periductal fibrosis but without lobules

 

Other images: #1#2#3#4

 

Virtual Slides

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Videos

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Cytology description

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Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Hamartoma: sharply circumscribed, has lobules, variable smooth muscle or cartilage, no periductal stromal changes

Pubertal macromastia: young patients, massive involvement

 

Additional references

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Stanford University

 

End of Breast-nonmalignant > Benign tumors / changes > Gynecomastia-like changes of female breast

 

 

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