Breast nonmalignant
Hemorrhagic necrosis in breast

Topic Completed: 1 April 2010

Minor changes: 22 August 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Hemorrhagic necrosis in breast

Hind Warzecha, M.D.
Page views in 2019: 346
Page views in 2020 to date: 123
Cite this page: Warzecha H. Hemorrhagic necrosis in breast. website. Accessed May 31st, 2020.
Definition / general
  • Associated with protein S / C deficiency
  • Warfarin induces paradoxical thrombosis in breast and other areas of excessive fat
  • Warfarin reduces synthesis of both vitamin K dependent procoagulant factors and inhibitors of coagulation (including proteins S / C) but in patients with existing reductions of proteins S or C, the major clinical effect is towards thrombosis
Case reports
  • May require mastectomy
Clinical images

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Hemorrhagic necrosis of breast

Microscopic (histologic) description
  • Widespread necrosis with multiple small vessel thrombi
Microscopic (histologic) images

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Venous thrombosis and necrotizing arteritis

Necrotizing arteritis

Intimal necrosis of artery

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