Breast - nonmalignant
Inflammatory / infectious
Hemorrhagic necrosis in breast

Author: Hind Nassar, M.D. (see Authors page)

Revised: 26 July 2017, last major update April 2010

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PubMed Search: Hemorrhagic necrosis in breast

Cite this page: Hemorrhagic necrosis in breast. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breasthemorrhagicnecrosis.html. Accessed October 22nd, 2017.
Definition / general
Etiology
  • Associated with protein S / C deficiency
  • Warfarin induces paradoxical thrombosis in breast and other areas of excessive fat
  • Warfarin reduces synthesis of both vitamin K dependent procoagulant factors and inhibitors of coagulation (including proteins S / C) but in patients with existing reductions of proteins S or C, the major clinical effect is towards thrombosis
Case reports
Treatment
  • May require mastectomy
Clinical images

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Hemorrhagic necrosis of breast

Microscopic (histologic) description
  • Widespread necrosis with multiple small vessel thrombi
Microscopic (histologic) images

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Venous thrombosis and necrotizing arteritis

Necrotizing arteritis

Intimal necrosis of artery