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Breast-nonmalignant
Inflammatory / infectious
Infarct
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 8 April 2010, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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Terminology
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Epidemiology
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● Most common during pregnancy or post-partum
● Associated with intraductal papilloma, fibroadenoma, pregnancy-like hyperplasia, lactating adenoma or phyllodes tumor, possibly due to interruption of blood supply
● Associated with fine needle aspiration (Arch Pathol Lab Med 1996;120:1069)
Etiology
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Clinical features
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● May be spontaneous (J Clin Pathol 1975;28:937)
● Special stains (reticulin or trichrome) may demonstrate residual fibrous structure
Prognostic factors
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Case reports
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● 31 year old pregnant woman with infarcted lactating adenoma (AJR Am J Roentgenol 1999;173:933)
Treatment
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Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Necrosis and ghost cells, hemosiderin; usually no thrombi are identified
Micro images
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Infarct in post-partum breast Outlines of ductules in
with lactational change infarcted tissue
Sharply circumscribed border Partial infarction of hyperplastic
lobules
Infarct with foamy macrophages Organizing thrombus in vein
Partial luminal obliteration of Coagulative necrosis of hyperplastic
medium sized vessels (elastic stain) lobules (reticulin stain)
Infarcted lactating adenoma; note zonal pattern
Virtual Slides
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Videos
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Cytology description
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● Initially degenerated cells with smudged nuclei, ghost cells and necrotic debris; later fibroblasts, ductal cells and necrotic debris (Diagn Cytopathol 2006;34:373)
Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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Additional references
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End of Breast-nonmalignant > Inflammatory / infectious > Infarct
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