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Breast-nonmalignant

Inflammatory / infectious

Infarct

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 27 September 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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Terminology

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Epidemiology

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● Most common during pregnancy or post-partum

● Associated with intraductal papilloma, fibroadenoma, pregnancy-like hyperplasia, lactating adenoma or phyllodes tumor, possibly due to interruption of blood supply

● Associated with fine needle aspiration (Arch Pathol Lab Med 1996;120:1069)

 

Etiology

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Clinical features

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● May be spontaneous (J Clin Pathol 1975;28:937)

● Special stains (reticulin or trichrome) may demonstrate residual fibrous structure

 

Prognostic factors

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Case reports

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● 31 year old pregnant woman with infarcted lactating adenoma (AJR Am J Roentgenol 1999;173:933)

 

Treatment

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Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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● Necrosis and ghost cells, hemosiderin; usually no thrombi are identified

 

Micro images

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Infarct in post-partum breast                                          Outlines of ductules in

with lactational change                                                    infarcted tissue

 

 

                                                               

Sharply circumscribed border                                       Partial infarction of hyperplastic

lobules

 

 

                                                               

Infarct with foamy macrophages                                   Organizing thrombus in vein

 

 

                                                                               

Partial luminal obliteration of                                          Coagulative necrosis of hyperplastic

medium sized vessels (elastic stain)                           lobules (reticulin stain) 

 

 

      

Infarcted lactating adenoma; note zonal pattern

 

Virtual Slides

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Videos

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Cytology description

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● Initially degenerated cells with smudged nuclei, ghost cells and necrotic debris; later fibroblasts, ductal cells and necrotic debris (Diagn Cytopathol 2006;34:373)

 

Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Additional references

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End of Breast-nonmalignant > Inflammatory / infectious > Infarct

 

 

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