Breast nonmalignant

Topic Completed: 1 April 2010

Revised: 22 August 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Infarct [title] breast

Hind Warzecha, M.D.
Page views in 2018: 431
Page views in 2019 to date: 378
Cite this page: Warzecha H. Infarct. website. Accessed August 25th, 2019.
  • Most common during pregnancy or postpartum
  • Associated with intraductal papilloma, fibroadenoma, pregnancy-like hyperplasia, lactating adenoma or phyllodes tumor, possibly due to interruption of blood supply
  • Associated with fine needle aspiration (Arch Pathol Lab Med 1996;120:1069)
Clinical features
  • May be spontaneous (J Clin Pathol 1975;28:937)
  • Special stains (reticulin or trichrome) may demonstrate residual fibrous structure
Case reports
Microscopic (histologic) description
  • Necrosis and ghost cells, hemosiderin; usually no thrombi are identified
Microscopic (histologic) images

AFIP images

Infarct in
breast with
lactational change

Outlines of ductules in infarcted tissue

Images hosted on other servers:

Sharply circumscribed border

Partial infarction of hyperplastic lobules

Organizing thrombus in vein

Partial luminal
obliteration of
medium sized
vessels (elastic stain)

necrosis of
hyperplastic lobules
(reticulin stain)

Infarct with foamy macrophages

Infarcted lactating adenoma; note zonal pattern

Cytology description
  • Initially degenerated cells with smudged nuclei, ghost cells and necrotic debris; later fibroblasts, ductal cells and necrotic debris (Diagn Cytopathol 2006;34:373)
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