Breast - nonmalignant
Benign tumors / changes
Lactating adenoma of breast


Topic Completed: 1 April 2010

Revised: 17 January 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Lactating adenoma [title] breast
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Cite this page: Nassar H Lactating adenoma of breast. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastlactatingadenoma.html. Accessed April 23rd, 2019.
Definition / general
  • Well circumscribed mass, arising during or shortly after pregnancy, composed of cuboidal cells with actively secreting, closely packed glands
Epidemiology
  • Usually during or shortly after pregnancy
  • Most prevalent breast lesion in pregnant women and during postpartum period (puerperium)
Sites
  • May also develop in ectopic breast tissue in axilla, chest or vulva (along "milk line")
Etiology
  • May actually be a coalescence of hyperplastic lobules, not a true adenoma
  • May have common origin with tubular adenoma (Hum Pathol 1985;16:707)
Case reports
Gross description
  • Well circumscribed, lobulated, solitary or multiple, gray tan cut surface, frequent necrosis / infarction
Gross images

Contributed by Dr. Mark R. Wick


Images hosted on other servers:

Well circumscribed mass

Small cysts

Microscopic (histologic) description
  • Cuboidal cells with actively secreting, closely packed glands
  • Resembles pregnancy-like (pseudolactational) changes
  • Resembles fibroadenoma or tubular adenoma with lactational change microscopically
Microscopic (histologic) images

Contributed by Dr. Mark R. Wick



Images hosted on other servers:

Well circumscribed

Invasive carcinoma

Focus of hyperplasia

Actively secreting epithelial cells

Greatly expanded lobules

Apical cytoplasmic blebs


Lactating adenoma

Stroma and dilated ectatic glands - H&E


Infarcted lactating adenoma - A: edge of infarction, B: hemosiderin laden macrophages, C: peripheral fibrosis, D: viable tumor, E: capsule

Orderly arrangement of glands

Clear vacuolization

Cytology description
Cytology images

Contributed by Dr. Mark R. Wick

FNAB



Images hosted on other servers:

Increased lobular size

Cytoplasmic vacuoles and background foamy material

Differential diagnosis
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