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Breast-nonmalignant
Benign tumors / changes
Lipoma of breast
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 8 October 2012, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Tumor of mature fat cells without atypia
Terminology
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● See also angiolipoma, chondrolipoma, spindle cell lipoma
Epidemiology
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● Most common benign tumor of male and female breast
● Usually ages 40-60 years
Sites
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● Usually subcutaneous; less often intramammary
Etiology
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Clinical features
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● Asymptomatic, mobile, solitary
● Recommended to confirm clinical and radiologic impression of lipoma with FNA, core biopsy or excision if necessary (Breast 2004;13:408)
Prognostic factors
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Case reports
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● 58 year old woman with giant lipoma of underlying pectoralis muscle simulating malignancy (Ann Acad Med Singapore 2005;34:275)
Treatment
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● Excision usually not necessary, except to exclude other diagnoses
Clinical images
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Gross description (Macroscopy)
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● Well circumscribed, thinly encapsulated, usually < 5 cm
Gross images
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Micro description (Histopathology)
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● Sheets of mature adipocytes without lipoblasts or atypia
● Resembles surrounding fat
Micro images
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Mature adipose tissue without atypia
Virtual Slides
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Videos
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Cytology description
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● Fat cells
Cytology images
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Positive stains
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● S100, CD34
Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Fatty area of breast tissue without encapsulation
Additional references
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End of Breast-nonmalignant > Benign tumors / changes > Lipoma
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