Breast nonmalignant
Lymphocytic mastitis (mastopathy)

Topic Completed: 1 April 2010

Minor changes: 4 September 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Lymphocytic mastitis breast [title]

Hind Warzecha, M.D.
Page views in 2019: 7,575
Page views in 2020 to date: 3,355
Cite this page: Warzecha H. Lymphocytic mastitis (mastopathy). website. Accessed May 31st, 2020.
Definition / general
  • Uncommon finding associated with type I diabetes
  • Also called lymphocytic mastopathy, diabetic mastopathy
  • Called sclerosing lymphocytic mastitis / lobulitis if prominent fibrosis
Clinical features
  • Rarely associated with DCIS
  • No increased risk of lymphoma
Radiology images

Contributed by Dr. Mark R. Wick


Images hosted on other servers:

Various images

Case reports
Gross description
  • Clinically palpable mass, usually subareolar
  • Gray white, smooth cut surface
  • Often bilateral
Microscopic (histologic) description
  • Ill defined lesion of dense intralobular, perilobular and perivascular lymphocytes
  • Also lobular atrophy and sclerosis (keloidal fibrosis), B cell lymphoepithelial lesions, lymphoid follicles with germinal centers
  • Also histiocytes and fibroblasts
  • Epithelioid fibroblasts may be mistaken for carcinoma or granular cell tumor (Mod Pathol 1994;7:49)
  • Variable fat necrosis and noncaseating granulomas
  • No changes in overlying epidermis
Microscopic (histologic) images

AFIP images

Perivascular lymphocytic infiltrate sparing lobules

 Contributed by Dr. Mark R. Wick

Lymphocytic mastitis

Case of the Week #337

51 year old diabetic woman - various images

Images hosted on other servers:

Various images

Findings in men: periductal lymphocytes and dense collagenous stroma

Type I diabetes for 20 years, 5 cm large, moderately coarse nodes, H&E

Cytology description
  • Clusters of ductal cells, lymphocytes and epithelioid fibroblasts in fragments of dense connective tissue (Acta Cytol 1997;41:1349)
Positive stains
  • B cell markers
Molecular / cytogenetics description
Differential diagnosis
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