Breast malignant, males, children - Basal cell carcinoma of nipple

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Breast malignant, males, children

Carcinoma subtypes

Basal cell carcinoma of nipple

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 15 November 2012, last major update March 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Terminology
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● Not in WHO breast classification
● See also Skin-Nonmelanocytic tumors chapter

Epidemiology
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● Very rare (< 50 cases reported), usually age 60+ years, equal distribution between men and women

Clinical
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● May behave aggressively with axillary nodal metastases

Treatment and prognosis
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● No consensus - wide local excision, mastectomy, radiation therapy
● Patients should be followed up for primary site recurrence and axillary metastasis as there is greater incidence than with BCC at other anatomical sites (Dermatol Surg 2009;35:1771)
● Photodynamic therapy proposed as an alternative in superficial tumors (Onkologie 2010;33:613)

Case reports
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● 47 year old woman (Onkologie 2010;33:613)
● 59 year old man with metastatic tumor to axillary nodes (Arch Pathol Lab Med 1986;110:761)
● 67 year old man (Arch Pathol Lab Med 2004;128:792)
● 74 year old woman (Ann Saudi Med 2007;27:296)

Clinical images
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Fungating, ulcerated, bleeding mass

Pigmented lesion

Micro description
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● Proliferating nests of basaloid cells arising from epidermis and extending into superficial dermis and nipple stroma
● May involve underlying lactiferous ducts

Micro images
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Various images

Nodules of basal cell carcinoma

Pigmented lesion

Skin-not nipple: superficial tumor

Differential diagnosis
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● Paget’s disease: tumor cells are large with clear cytoplasm, not basaloid
● Bowen’s disease: in situ disease without invasion; cells typically are not basaloid

End of Breast malignant, males, children > Carcinoma subtypes > Basal cell carcinoma of nipple

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