Breast malignant, males, children
Carcinoma subtypes
Lymphoepithelioma-like carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 September 2018, last major update August 2012

Copyright: (c) 2001-2018,, Inc.

PubMed search: lymphoepithelioma-like carcinoma breast

Cite this page: Roychowdhury, M. Lymphoepithelioma-like carcinoma. website. Accessed October 24th, 2018.
Definition / general
  • Rare in breast, more common in pharynx
  • Not part of WHO breast classification
  • Usually older patients
Case reports
Gross description
  • Multiple nodules, without circumscription
Microscopic (histologic) description
  • Dense inflammatory infiltrate of mature round lymphocytes and lymphoid follicles with occasional plasma cells, histiocytes and eosinophils
  • Also single large cells with abundant pale cytoplasm, large vesicular nuclei, prominent nucleolus and infiltrative pattern at margin of tumor
  • Occasional mitotic figures
  • Lymphoid cells "cuff" large cells in rosette-like manner
  • Tumor cells are occasionally pleomorphic and multinucleated with lymphophagocytosis
  • Also lobulocentric lymphoid infiltrate in hyalinized, sclerotic stroma
Microscopic (histologic) images
Images hosted on other servers:

Various images

Bladder: high grade tumor cells in sheets and nests; AE1 / AE3


Strong cytoplasmic staining

Positive stains
Differential diagnosis
Additional references