Other carcinoma subtypes, not WHO classified

Topic Completed: 1 August 2012

Minor changes: 21 June 2020

Copyright: 2001-2019,, Inc.

PubMed search: lymphoepithelioma-like carcinoma breast

Monika Roychowdhury, M.D.
Page views in 2019: 627
Page views in 2020 to date: 646
Cite this page: Roychowdhury M. Lymphoepithelioma-like. website. Accessed November 25th, 2020.
Definition / general
  • Rare in breast, more common in pharynx
  • Not part of WHO breast classification
  • Usually older patients
Case reports
Gross description
  • Multiple nodules, without circumscription
Microscopic (histologic) description
  • Dense inflammatory infiltrate of mature round lymphocytes and lymphoid follicles with occasional plasma cells, histiocytes and eosinophils
  • Also single large cells with abundant pale cytoplasm, large vesicular nuclei, prominent nucleolus and infiltrative pattern at margin of tumor
  • Occasional mitotic figures
  • Lymphoid cells "cuff" large cells in rosette-like manner
  • Tumor cells are occasionally pleomorphic and multinucleated with lymphophagocytosis
  • Also lobulocentric lymphoid infiltrate in hyalinized, sclerotic stroma
Microscopic (histologic) images

Images hosted on other servers:

Various images

Bladder: high grade tumor cells in sheets and nests; AE1 / AE3


Strong cytoplasmic staining

Positive stains
Differential diagnosis
Additional references
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