Breast
Other carcinoma subtypes, not WHO classified
Lymphoepithelioma-like


Topic Completed: 1 August 2012

Minor changes: 21 June 2020

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PubMed search: lymphoepithelioma-like carcinoma breast

Monika Roychowdhury, M.D.
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Cite this page: Roychowdhury M. Lymphoepithelioma-like. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantLEL.html. Accessed November 25th, 2020.
Definition / general
  • Rare in breast, more common in pharynx
Terminology
  • Not part of WHO breast classification
Epidemiology
  • Usually older patients
Case reports
Gross description
  • Multiple nodules, without circumscription
Microscopic (histologic) description
  • Dense inflammatory infiltrate of mature round lymphocytes and lymphoid follicles with occasional plasma cells, histiocytes and eosinophils
  • Also single large cells with abundant pale cytoplasm, large vesicular nuclei, prominent nucleolus and infiltrative pattern at margin of tumor
  • Occasional mitotic figures
  • Lymphoid cells "cuff" large cells in rosette-like manner
  • Tumor cells are occasionally pleomorphic and multinucleated with lymphophagocytosis
  • Also lobulocentric lymphoid infiltrate in hyalinized, sclerotic stroma
Microscopic (histologic) images

Images hosted on other servers:

Various images

Bladder: high grade tumor cells in sheets and nests; AE1 / AE3

Lympho-
epithelioma-like
carcinoma

Strong cytoplasmic staining

Positive stains
Differential diagnosis
Additional references
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