Lymphoepithelioma-like carcinoma

Breast malignant, males, children
Carcinoma subtypes
Lymphoepithelioma-like carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 December 2016, last major update August 2012

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PubMed search: lymphoepithelioma-like carcinoma breast

Table of Contents

Cite this page: Lymphoepithelioma-like carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantLEL.html. Accessed July 14th, 2017.

Definition / general

Rare in breast, more common in pharynx

Terminology

Not part of WHO breast classification

Epidemiology

Usually older patients

Case reports

45 year old woman with possible HPV association (Anticancer Res 2012;32:1435)
47 year old woman (Virchows Arch 2005;447:653)
50 year old woman with coexisting lymphocytic mastitis (Arch Pathol Lab Med 2001;125:669)
53 year old woman with preoperative FNA (Acta Cytol 2012;56:85)
65 year old woman (Mod Pathol 1994;7:129)
HPV18+ / HPV33+ tumor (Hum Pathol 2008;39:298)

Gross description

Multiple nodules, without circumscription

Microscopic (histologic) description

Dense inflammatory infiltrate of mature round lymphocytes and lymphoid follicles with occasional plasma cells, histiocytes and eosinophils
Also single large cells with abundant pale cytoplasm, large vesicular nuclei, prominent nucleolus and infiltrative pattern at margin of tumor
Occasional mitotic figures
Lymphoid cells "cuff" large cells in rosette-like manner
Tumor cells are occasionally pleomorphic and multinucleated with lymphophagocytosis
Also lobulocentric lymphoid infiltrate in hyalinized, sclerotic stroma

Microscopic (histologic) images

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