Breast – Malignant, Males, Children

Home Chapter Home Jobs Conferences Fellowships Books

Breast-malignant, males, children

Leiomyosarcoma

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 1 October 2009

Last major update: October 2009

Definition

=========================================================================

● Malignant smooth muscle tumor, rare in breast as a primary or metastases

Case reports

=========================================================================

● 50 year old woman with 10 year history of cyclophosphamide for SLE (Cases J 2008 Nov 7;1:301)

● 52 year old woman (J Zhejiang Univ Sci B 2008;9:109)

● 53 year old man with leiomyosarcoma of nipple (AJSP 1978;2:299)

Clinical images

=========================================================================

Necrotic breast mass

Microscopic description

=========================================================================

● Intersecting fascicles of spindle cells with moderate eosinophilic cytoplasm, cigar shaped nuclei with blunt ends, moderate nuclear atypia, frequent mitotic figures

Micro images

=========================================================================

Dense cellularity and intersecting fascicles Various images

Tumor cells have moderate eosinophilic cytoplasm, Nuclear pleomorphism and

cigar-shaped nuclei with blunt ends, and moderate mitotic activity (AFIP)

nuclear atypia, with mitotic figures present

Cellular pleomorphic tumor Tumor of nipple-areolar complex

Alpha smooth muscle actin+

Cytology description

=========================================================================

● Large, dissociated round to spindle cells, medium to large, with abundant vacuolated cytoplasm with occasional intranuclear cytoplasmic invaginations; cells have pleomorphic nuclei, prominent nucleoli

● Also mitotic figures, osteoclast-like giant cells and stromal fragments (Diagn Cytopathol 2003;29:172, Acta Cytol 2008;52:485)

Cytology images

=========================================================================

Various images (pdf)

Positive stains

=========================================================================

● Actin, desmin, vimentin

Negative stains

=========================================================================

● Keratin, S100, CD34

Molecular / cytogenetics

=========================================================================

● 10q-, 13q-

● Also 17p-, 1q+, 17p+ (Cancer Genet Cytogenet 2004;149:53)

Differential diagnosis

=========================================================================

● Metastatic tumor (Diagn Cytopathol 2007;35:508, Ir J Med Sci 2009 Jan 31 [Epub ahead of print])

End of Breast – Malignant, Males, Children > Leiomyosarcoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by Copyright, (c) 2001-2009, PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions.