Breast malignant, males, children

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Breast malignant, males, children

Sarcoma

Rhabdomyosarcoma

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 15 November 2012, last major update November 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Definition
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● Malignant tumor with features of skeletal muscle differentiation
● Primary or secondary (Pediatr Hematol Oncol 1996;13:277)

Epidemiology
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● Very rare (Chin Med J (Engl) 2012;125:2618), usually teenager girls with alveolar subtype

Case reports
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● 13 year old girl (Surg Today 2007;37:38)
● 51 year old woman (Arch Pathol Lab Med 1998;122:747)

Gross description
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● Round or oval, well-demarcated but non-encapsulated masses
● Hard or soft; cut surface has homogeneous grayish yellow or white tissue with focal necrosis

Micro description
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● Primitive myoblasts and rhabdomyoblasts with cytoplasmic cross striations
● Usually alveolar subtype (Med Pediatr Oncol 1997;29:181)
● Poorly-differentiated small round or polygonal cells with sparse eosinophilic cytoplasm
● Nuclei are round/oval and densely stained
● Frequent mitotic figuresd
● “Racquet” and “strap” cells with peripherally placed nuclei are specific

Micro images
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Variable skeletal muscle differentiation

Positive stains
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● Vimentin, desmin, MyoD1, myogenin

Negative stains
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● Cytokeratin AE1/AE3

Differential diagnosis
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● Malignant phyllodes tumor: may have rhabdomyosarcomatous differentiation, but also has phyllodes component
● Metaplastic carcinoma: has epithelial component

End of Breast malignant, males, children > Sarcoma > Rhabdomyosarcoma

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