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Table of Contents
Definition / general | Terminology | Clinical features | Case reports | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Positive stains | Negative stains | Electron microscopy description | Differential diagnosis | Additional referencesCite this page: Adenosquamous carcinoma - low grade. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantadenosquamous.html. Accessed July 14th, 2017.
Definition / general
- Carcinoma with well developed tubule / gland formation mixed with widely dispersed solid nests of squamous cells
Terminology
- Also called syringomatous carcinoma, adenocarcinoma with squamous differentiation
- See also mucoepidermoid carcinoma
Clinical features
- Uncommon; considered a rare variant of metaplastic breast carcinoma (Am J Surg Pathol 1987;11:351)
- May originate from an intraductal papillary tumor, or be associated with sclerosing adenosis, radial scar or ductal adenoma
- Recurs locally with conservative therapy, metastases unusual
- Difficult to diagnose by fine needle aspiration, core biopsy or frozen section (Histopathology 2006;49:603)
Case reports
- 19 year old woman with adenosquamous carcinoma of breast (World J Surg Oncol 2010 May 27;8:44)
Gross description
- Mean 2 - 3 cm, range 1 - 9 cm
- Hard, tannish yellow, infiltrative
Gross images
Images hosted on PathOut server:
Images from AFIP:
Images from AFIP:
Well circumscribed mass
Microscopic (histologic) description
- Resembles syringomatous adenoma of nipple; often originates from intraductal papillary tumor
- Has tadpole or comma shaped epithelial structures with inner epithelial cells and outer myoepithelial cells
- Also other areas of obvious squamous differentiation, desmoplastic stroma
- Often keratinizing squamous component
Microscopic (histologic) images
Images hosted on PathOut server:
Images from AFIP (Third Series):
DCIS in large duct
below / at arrows
giving rise to adeno-
squamous carcinoma
Images hosted on other servers:
Nature.com images:
Images from AFIP (Third Series):
Neoplastic ductules around a lobule
Neoplastic ductules with secretion and squamous area
below / at arrows
giving rise to adeno-
squamous carcinoma
Invasive ductal elements
with syringomatous features
in dense collagenous stroma
Images hosted on other servers:
Various images
Nature.com images:
Various images
Cytology description
- Proliferating ductal cells and atypical squamous cells in the same cell clusters (Pathol Int 1997;47:264)
Positive stains
Negative stains
- ER, PR (Pathol Annu 1994;29:181)
- Often triple negative tumors (ER-, PR-, HER2-, Mod Pathol 2010;23:951)
Electron microscopy description
- Glandular and squamous differentiation
- Squamous cells resemble acrosyringium of eccrine sweat gland
Differential diagnosis
- Syringomatous adenoma of nipple: similar histology, but more superficial, involving nipple areolar complex; benign
Additional references
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