Breast malignant, males, children
Carcinoma subtypes
Apocrine carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 22 December 2016, last major update March 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed search: Apocrine carcinoma [title] breast

Cite this page: Apocrine carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantapocrine.html. Accessed December 12th, 2017.
Definition / general
  • > 90% of tumor cells have cytologic or immunohistochemical features of apocrine cells
  • Rare, 1% - 4% of all breast carcinomas
Prognostic factors
Case reports
  • 71 year old woman with apocrine adenocarcinoma of the nipple (Cases J 2008;1:88)
  • 84 year old woman had a total mastectomy with axillary dissection for a breast nodule (Case of the Week #68)
Gross description
Microscopic (histologic) description
  • Tumor cells have distinct cell margins, abundant acidophilic cytoplasm with eosinophilic granules, central to eccentric vesicular nuclei with prominent nucleoli
  • May have glandular differentiation with apocrine snouts and prominent nucloeoli
  • Limit diagnosis to tumors with widespread apocrine change and obvious malignancy
  • Type A cells: abundant granular and intensely eosinophilic cytoplasm, granules are PAS+ diastase resistant, nuclei vary from globoid with prominent nucleoli to hyperchromatic
  • Type B cells: abundant cytoplasm with fine empty vacuoles, creating a foamy appearance resembling histiocytes, nuclei are similar to type A cells
  • Exclude: cases with clear cells of any type in any amount; other subtypes including tubular, lobular, mucinous, invasive micropapillary or medullary
Microscopic (histologic) images
Scroll to see all images.

Images hosted on PathOut server:

Missing Image

Courtesy of Dr. Mark R. Wick

GCDFP-15

bcl2 negative



Images from AFIP:

Solid growth (AFIP)

Histiocytoid variant with isolated
cells resembling histiocytes
in desmoplastic stroma,
resembles granular cell tumor



Case of the Week #68:

Case of the week images



Flickr images:

Contributed by Dr. Semir Vranic, Sarajevo

GCDFP-15

AR expression, 20x


Estrogen receptor, 20x

HER2, 20x

HER2 gene, CISH 2





Images hosted on other servers:

Abundant cytoplasm with distinct cell margins

Cytoplasm is granular, nuclei are round

Cells have abundant cytoplasm with distinct cell margins


Cytoplasm is granular, nuclei are round with prominent nucleoli


With apocrine DCIS

Missing Image

Vesicular nuclei

Missing Image

Cancerization of lobule


H&E

GCDFP-15

Positive stains
Negative stains
Electron microscopy description
  • Prominent mitochondria, some with abnormal cristae
  • Large membrane bound vesicles with dense homogenous osmophilic cores
Electron microscopy images
Images hosted on PathOut server:

AFIP Fascicle Third Series:

Smooth and rough
endoplasmic
reticulum,
dense nucleoli

Cytokeratin fila-
ments (arrow), lipid
droplets, mito-
chondria, lysosomes

Cytoplasm contains numerous
lysosomes, lipid droplets,
dilated mitochondria and
vesicular endoplasmic reticulum



Images hosted on other servers:

Cytoplasm rich in organelles

Electron dense
granules, condensed, at
secretory pole of cell

Molecular / cytogenetics description
  • Form a distinct, even if heterogeneous, molecular subgroup of breast carcinomas that recapitulate the phenotype of apocrine sweat glands (Mol Oncol 2009;3:220)
  • Abnormalities at 7q (codes for GCDFP-15 and prolactin inducible protein)
  • Also loss of heterozygosity for p53 gene, VHL (3p25) gene, NB gene (1p35-36), PKD1/TSC2 gene at 16p13 (Mod Pathol 1999;12:1083)
Differential diagnosis