Basal-like DCIS

Breast malignant, males, children
In situ carcinoma
Basal-like DCIS

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 18 October 2016, last major update February 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Basal like DCIS

Table of Contents

Cite this page: Basal-like DCIS. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantbasallikeDCIS.html. Accessed July 14th, 2017.

Definition / general

Classified based on immunohistochemistry or gene expression profiling (Breast Cancer Res 2006;8:R61), not morphology
8% of DCIS
Of academic interest only, not currently used clinically

Epidemiology

Associated with high grade nuclei, p53 overexpression, increased Ki67 index (Hum Pathol 2007;38:197), but only a small percentage of high grade DCIS has basal-like phenotype (Mod Pathol 2006;19:617)
Commonly found with invasive basal-like carcinomas (Mod Pathol 2006;19:1506)
DCIS lesions in BRCA1 mutation carriers are mostly basal-like (J Clin Pathol 2009;62:926)

Microscopic (histologic) description

Solid, flat or micropapillary
High nuclear grade, comedonecrosis, intense lymphocytic infiltrate

Microscopic (histologic) images

Images hosted on Nature servers:

H&E and stains

H&E and variable CK5/6 staining

Positive stains

CK5/6, CK14 or CK17
Usually EGFR or c-kit/CD117
Also vimentin, alphaB-crystallin (Ann Diagn Pathol 2008;12:33), p-cadherin (Virchows Arch 2007;450:73)

Negative stains

By definition is ER-, PR- and HER2-