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Breast malignant, males, children

In situ carcinoma

Basal-like DCIS

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 4 February 2012, last major update February 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Classified based on immunohistochemistry or gene expression profiling (Breast Cancer Res 2006;8:R61), not morphology
● 8% of DCIS
● Of academic interest only, not currently used clinically

Epidemiology
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● Associated with high grade nuclei, p53 overexpression, increased Ki-67 index (Hum Pathol 2007;38:197), but only a small percentage of high grade DCIS has basal-like phenotype (Mod Pathol 2006;19:617)
● Commonly found with invasive basal-like carcinomas (Mod Pathol 2006;19:1506)
● DCIS lesions in BRCA1 mutation carriers are mostly basal-like (J Clin Pathol 2009;62:926)

Micro description
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● Solid, flat or micropapillary
● High nuclear grade, comedonecrosis, intense lymphocytic infiltrate

Micro images
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H&E and stains


H&E and variable CK5/6 staining

Positive stains
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● CK5/6, CK14 or CK17
● Usually EGFR or c-kit/CD117
● Also vimentin, alphaB-crystallin (Ann Diagn Pathol 2008;12:33), P-cadherin (Virchows Arch 2007;450:73)

Negative stains
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● By definition is ER-, PR- and HER2-

End of Breast malignant, males, children > In situ carcinoma > Basal-like DCIS

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