Breast
Other carcinoma subtypes, not WHO classified
BRCA2 carcinoma


Topic Completed: 1 April 2012

Minor changes: 21 June 2020

Copyright: 2001-2019, PathologyOutlines.com, Inc.

PubMed search: BRCA2 associated [title] carcinoma breast

Monika Roychowdhury, M.D.
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Cite this page: Roychowdhury M. BRCA2 carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantbrca2.html. Accessed November 25th, 2020.
Definition / general
  • BRCA2 associated breast cancer is not part of WHO breast classification
  • BRCA2 is a tumor suppressor gene at 13q12-13 (OMIM 600185)
  • See also Stains chapter
Epidemiology
  • 12% of women referred for genetic testing have BRCA1 / BRCA2 deleterious mutations, rate is similar among different ancestries (Cancer 2009;115:2222), but higher in Ashkenazi Jewish women
  • Manchester scoring system assesses individual risk of BRCA1 / 2 mutations (J Med Genet 2009;46:811)
  • 60% - 75% with germline mutations get breast cancer by age 70, 88% at age 80 (BMC Cancer 2008;8:155), but usually by age 50
  • Patients also have higher risk of cancers of ovary (39% - 63%), bone, pharynx, prostate, pancreas (J Med Genet 2005;42:711); also other organs
  • Slightly more frequent in black (2.6%) versus white (2.1%) American patients (Cancer Res 2006;66:8297)
  • For patients with 10% or lower risk of BRCA1 / 2 mutation, genetic screening is not cost effective (Value Health 2009;12:207)
Case reports
Microscopic (histologic) description
Microscopic (histologic) images

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Typical histological patterns

Various immunostains

Positive stains
Negative stains
  • CK5 (usually), HER2 (usually)
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