Breast malignant
BRCA2 associated breast carcinoma

Topic Completed: 1 April 2012

Revised: 30 October 2019

Copyright: 2001-2019,, Inc.

PubMed search: BRCA2 associated [title] carcinoma breast

Monika Roychowdhury, M.D.
Page views in 2018: 301
Page views in 2019 to date: 323
Cite this page: Roychowdhury M. BRCA2 associated breast carcinoma. website. Accessed November 12th, 2019.
Definition / general
  • BRCA2 associated breast cancer is not part of WHO breast classification
  • BRCA2 is a tumor suppressor gene at 13q12-13 (OMIM 600185)
  • See also Stains chapter
  • 12% of women referred for genetic testing have BRCA1 / BRCA2 deleterious mutations, rate is similar among different ancestries (Cancer 2009;115:2222), but higher in Ashkenazi Jewish women
  • Manchester scoring system assesses individual risk of BRCA1 / 2 mutations (J Med Genet 2009;46:811)
  • 60% - 75% with germline mutations get breast cancer by age 70, 88% at age 80 (BMC Cancer 2008;8:155), but usually by age 50
  • Patients also have higher risk of cancers of ovary (39% - 63%), bone, pharynx, prostate, pancreas (J Med Genet 2005;42:711); also other organs
  • Slightly more frequent in black (2.6%) versus white (2.1%) American patients (Cancer Res 2006;66:8297)
  • For patients with 10% or lower risk of BRCA1 / 2 mutation, genetic screening is not cost effective (Value Health 2009;12:207)
Case reports
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on other servers:

Typical histological patterns

Various immunostains

Positive stains
Negative stains
  • CK5 (usually), HER2 (usually)
Back to top