Breast malignant, males, children
Carcinoma subtypes
General

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 2 December 2016, last major update February 2012

Copyright: (c) 2001-2016, PathologyOutlines.com, Inc.

PubMed search: breast carcinoma [title] subtypes WITH malignan

Cite this page: General. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantcarcinomasubtypesgeneral.html. Accessed December 5th, 2016.
Definition / General
Positive Stains
Molecular / Cytogenetics Description
  • DNA microarray profiling studies have divided invasive breast carcinoma into molecular subtypes: luminal A (ER+, HER2–), luminal B (ER+, HER2+), HER2 positive (ER–, HER2+), normal breast-like (ER+, PR+, HER2–) and basal-like (ER–, HER2–, EGFR+ or cytokeratin 5 / 6+)
  • Most histologic subtypes other than lobular and apocrine belong to only one molecular subtype (J Pathol 2008;216:141)
  • By hierarchical clustering analysis, some histological subtypes types appear to be discrete entities (micropapillary carcinoma), but others appear similar to each other (tubular and lobular)
Additional References