Breast malignant, males, children
Carcinoma subtypes
Central acellular carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 26 December 2016, last major update October 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: central acellular [title] carcinoma breast

Cite this page: Central acellular carcinoma. website. Accessed June 20th, 2018.
Definition / general
  • Not in WHO breast classification
  • Aggressive behavior despite small size and minimal nodal involvement
  • Also called invasive ductal carcinoma with large central acellular zone, ring carcinoma, central necrotizing carcinoma
Clinical features
Prognostic factors
  • Poorer prognosis than matched patients with poorly differentiated tumors containing less extensive necrosis
Microscopic (histologic) description
  • Well circumscribed, solitary nodule with extensive central necrosis or collagen / hyaline deposition, constituting a majority of tumor volume, surrounded by a narrow rim of viable high grade tumor cells (ring-like hypercellular zone) with pushing border and minimal tubule formation
  • Relatively sharp margin but infiltrative growth accompanied by eosinophilic intercellular matrix
  • Abrupt transition between peripheral cellular and central acellular zones without alteration of cancer cell adhesion (Pathol Int 2009;59:390)
Microscopic (histologic) images
Images hosted on PathOut server:

Tumor with well circumscribed borders and central necrosis

Positive stains
Negative stains
Differential diagnosis