Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Breast malignant, males, children

In situ carcinoma

Clinging DCIS


Reviewer: Dina Kandil, M.D. (see Reviewers page)
Revised: 3 November 2012, last major update January 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Definition
=========================================================================

● Terminology is no longer widely used
● Typically used to describe high-grade DCIS with comedonecrosis, in which the necrosis is so extensive that only 1 or 2 layers are present at the periphery
● Although controversial, it is preferable not to use this term to describe columnar cell hyperplasia with atypia or flat epithelial lesion, to avoid overtreatment (Breast Cancer Res 2003;5:263)

Micro description
=========================================================================

● 1-2 layers of malignant cells lining a gland with a large empty lumen
● Tumor cells are highly atypical and often associated with extensive comedo necrosis

Differential diagnosis
=========================================================================

Flat epithelial atypia: dilated ducts lined by 1 or several layers of cuboidal or columnar cells with atypia resembling low-grade DCIS; prominent apical cytoplasmic snouts are very common

End of Breast malignant, males, children > In situ carcinoma > Clinging DCIS


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).