Breast malignant, males, children

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Breast malignant, males, children

In situ carcinoma

Clinging DCIS

Reviewer: Dina Kandil, M.D. (see Reviewers page)
Revised: 10 January 2012, last major update January 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Definition
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● Terminology is no longer widely used
● Typically used to describe high-grade DCIS with comedonecrosis, in which the necrosis is so extensive that only 1 or 2 layers are present at the periphery
● Although controversial, it is preferable not to use this term to describe columnar cell hyperplasia with atypia or flat epithelial lesion, to avoid overtreatment (Breast Cancer Res 2003;5:263)

Micro description
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● 1-2 layers of malignant cells lining a gland with a large empty lumen
● Tumor cells are highly atypical and often associated with extensive comedo necrosis

Differential diagnosis
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● Flat epithelial atypia: dilated ducts lined by 1 or several layers of cuboidal or columnar cells with atypia resembling low-grade DCIS; prominent apical cytoplasmic snouts are very common

End of Breast malignant, males, children > In situ carcinoma > Clinging DCIS

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