Cite this page: Clinging DCIS. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantclingingDCIS.html. Accessed March 24th, 2017.
Definition / General
- Terminology is no longer widely used
- Typically used to describe high-grade DCIS with comedonecrosis, in which the necrosis is so extensive that only 1 or 2 layers are present at the periphery
- Although controversial, it is preferable not to use this term to describe columnar cell hyperplasia with atypia or flat epithelial lesion, to avoid overtreatment (Breast Cancer Res 2003;5:263)
- 1 - 2 layers of malignant cells lining a gland with a large empty lumen
- Tumor cells are highly atypical and often associated with extensive comedo necrosis
- Flat epithelial atypia: dilated ducts lined by 1 or several layers of cuboidal or columnar cells with atypia resembling low grade DCIS; prominent apical cytoplasmic snouts are very common