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Breast malignant, males, children


Treatment effect - cryoprobe

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 18 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Clinical features

Cryoprobe: uses cryotherapy to makes nonpalpable carcinomas well-defined and palpable by creating an ice ball, leading to removal of less tissue (Am J Surg 2006;192:462)
● Alters tumor morphology making it difficult to grade tumor, distinguish DCIS and invasive tumor, and identify angiolymphatic invasion or mitotic figures (Am J Clin Pathol 2007;128:239)
● Alternative to excision of fibroadenomas (Radiology 2005;234:63)
● Normal breast parenchyma in cryozone shows dense fibrosis, fat necrosis, xanthogranulomatous reaction, endovascular fibrosis and hemorrhage (Cryobiology 2007;55:44)
● Causes reduction in ER/PR receptors, but does not affect Ki-67 staining or margin evaluation

Micro images

Post-cryoprobe ablation shows coagulative   Residual invasive ductal carcinoma
necrosis and amorphous eosinophilic staining

Cryoprobe related artifact (fig B)        Cellular shrinkage, smudgy nuclei
compared to core biopsy (fig A)         and prominent retraction artifact

Acellular central hyaline background
without residual fibroadenoma

End of Breast malignant, males, children > Miscellaneous > Treatment effect - cryoprobe

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