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Breast malignant, males, children

Carcinoma subtypes

Ductal NOS - Carcinoma with osteoclastic giant cells


Reviewer: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 21 April 2014, last major update October 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Part of WHO classification
● Osteoclastic giant cells are present in stroma
● Presence of giant cells does not alter prognosis

Case reports
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● 44 year old and 83 year old women (Diagn Pathol 2010;23:55)
● 46 year old woman (Radiographics 2002;22:691)
● 51 year old woman with pleomorphic carcinoma and prominent osteoclastic giant cells (Pathol Int 2009;59:91)
● Cases with neuroendocrine carcinoma (Pathologica 2008;100:176)

Gross description
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● Often brown due to vascular stroma with hemosiderin

Micro description
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● Giant cells are associated with vascular stroma with extravasated red blood cells and hemosiderin, also chronic inflammatory cells and fibroblasts
● Giant cells have variable size and variable numbers of nuclei
● Similar histologic features in nodal metastases and recurrences (Arch Pathol Lab Med 1986;110:636)
● Carcinoma component may be any type

Micro images
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Whole mount


Tubular growth, vascular stroma and hemorrhage

   
Giant cells in stroma and intraductal spaces

       
Various images, contributed by Semir Vranic

   
Various images

Various images: differentiated well cribriform carcinoma #1, #2, #3, osteoclast like giant cells in close contact to tumor cells

Cytology description
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● Abundant giant cells and mononucleated stromal cells associated with carcinoma cells (Diagn Cytopathol 2005;33:246)

Positive stains
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Osteoclastic giant cells: CD68; also acid phosphatase, lysosome, nonspecific esterase; also MMP9, TRAP, cathepsin K

Negative stains
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Osteoclastic giant cells: S100, actin, keratin, EMA, ER, PR, alkaline phosphatase

Electron microscopic description
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● Osteoclasts are histiocytes

Additional References
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Ann Pathol 1989;9:189, Hum Pathol 1990;21:1142
Stanford University

End of Breast malignant, males, children > Carcinoma subtypes > Ductal NOS - Carcinoma with osteoclastic giant cells


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