Breast malignant, males, children
Carcinoma subtypes
Ductal carcinoma, NOS - Carcinoma with osteoclastic giant cells

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 October 2016, last major update October 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Carcinoma with osteoclastic giant cells

Cite this page: Ductal carcinoma, NOS - Carcinoma with osteoclastic giant cells. website. Accessed December 13th, 2018.
Definition / general
  • Part of WHO classification
  • Osteoclastic giant cells are present in stroma
  • Presence of giant cells does not alter prognosis
Case reports
Gross description
  • Often brown due to vascular stroma with hemosiderin
Microscopic (histologic) description
  • Giant cells are associated with vascular stroma with extravasated red blood cells and hemosiderin, also chronic inflammatory cells and fibroblasts
  • Giant cells have variable size and variable numbers of nuclei
  • Similar histologic features in nodal metastases and recurrences (Arch Pathol Lab Med 1986;110:636)
  • Carcinoma component may be any type
Microscopic (histologic) images

Images hosted on Flickr:

Various images, courtesy of Semir Vranic

Images hosted on other servers:

Whole mount

Tubular growth, vascular stroma and hemorrhage

Giant cells in stroma and intraductal spaces

Various images

Differentiated well cribriform carcinoma

Osteoclast like giant cells in close contact to tumor cells

Cytology description
Positive stains
Negative stains
Electron microscopy description
  • Osteoclasts are histiocytes