Breast malignant, males, children - Pleomorphic carcinoma variant of ductal NOS

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Breast malignant, males, children

Carcinoma subtypes

Pleomorphic carcinoma variant of ductal NOS

Reviewer: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 10 October 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Part of WHO classification
● Variant of high grade ductal NOS with pleomorphic and bizarre tumor cells comprising 50% or more of tumor cells

Clinical description
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● Aggressive behavior

Case reports
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● 83 year old woman with pleomorphic tumor with predominantly micropapillary features (Pathol Int 2007;57:694)

Micro description
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● 50%+ of tumor has pleomorphic cell population (> 6X variation in nuclear size) (Histopathology 2000;36:505)
● Excludes tumors of lobular origin
● Adjacent DCIS or classic ductal carcinoma in 73%
● Usually brisk mitotic activity

Positive stains
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● CAM 5.2, pan-keratin, EMA
● p53 (2/3), S100 (1/3)

Negative stains
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● ER, PR, bcl2

Differential diagnosis
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● Sarcoma

Additional references
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● Pathologica 2011;103:68

End of Breast malignant, males, children > Carcinoma subtypes > Pleomorphic carcinoma variant of ductal NOS

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