Invasive breast carcinoma of no special type and variants

Topic Completed: 1 August 2012

Minor changes: 21 June 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Pleomorphic carcinoma [title]

Monika Roychowdhury, M.D.
Page views in 2019: 1,144
Page views in 2020 to date: 1,174
Cite this page: Roychowdhury M. Pleomorphic. website. Accessed November 23rd, 2020.
Definition / general
  • Part of WHO classification
  • Variant of high grade ductal NOS with pleomorphic and bizarre tumor cells comprising 50% or more of tumor cells
Clinical features
  • Aggressive behavior
Case reports
  • 83 year old woman with pleomorphic tumor with predominantly micropapillary features (Pathol Int 2007;57:694)
Microscopic (histologic) description
  • 50%+ of tumor has pleomorphic cell population (> 6X variation in nuclear size) (Histopathology 2000;36:505)
  • Excludes tumors of lobular origin
  • Adjacent DCIS or classic ductal carcinoma in 73%
  • Usually brisk mitotic activity
Microscopic (histologic) images

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Courtesy of Dr. Semir Vranic

Positive stains
Negative stains
Differential diagnosis
Additional references
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