Breast malignant, males, children
Carcinoma subtypes
Ductal carcinoma, NOS - pleomorphic variant

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 October 2016, last major update August 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Pleomorphic carcinoma [title]

Cite this page: Ductal carcinoma, NOS - pleomorphic variant. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantductalNOSpleomorphic.html. Accessed December 9th, 2016.
Definition / General
  • Part of WHO classification
  • Variant of high grade ductal NOS with pleomorphic and bizarre tumor cells comprising 50% or more of tumor cells
Clinical Features
  • Aggressive behavior
Case Reports
  • 83 year old woman with pleomorphic tumor with predominantly micropapillary features (Pathol Int 2007;57:694)
Micro Description
  • 50%+ of tumor has pleomorphic cell population (> 6X variation in nuclear size) (Histopathology 2000;36:505)
  • Excludes tumors of lobular origin
  • Adjacent DCIS or classic ductal carcinoma in 73%
  • Usually brisk mitotic activity
Micro Images

Images hosted on other servers:

Courtesy of Dr. Semir Vranic

Positive Stains
Negative Stains
Differential Diagnosis
Additional References