Breast
Breast cancer
Inflammatory


Topic Completed: 1 August 2012

Minor changes: 21 June 2020

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed search: Inflammatory carcinoma [title] breast

Monika Roychowdhury, M.D.
Page views in 2019: 4,541
Page views in 2020 to date: 2,490
Cite this page: Roychowdhury M. Inflammatory. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantinflamcar.html. Accessed July 13th, 2020.
Definition / general
  • A clinical (not pathologic) diagnosis of an enlarged, erythematous and edematous breast, presumed to be due to dermal plugging of lymphatic vessels by tumor (Breast Cancer Res 2005;7:52, Wikipedia)
Clinical features
  • Mean age 53 years
  • Tumor may not be palpable on clinical exam
  • Stage T4d in TNM classification
  • Peau d'orange: lymphatics are so involved by tumor microemboli that skin drainage is blocked, causing lymphedema and thickening of skin of majority of breast
Case reports
Treatment
  • Aggressive, with 5 year disease free survival < 45%, even if node negative (Arch Surg 2006;141:567)
  • Treated with neoadjuvant (preoperative) chemotherapy
Clinical images

Contributed by Dr. Mark R. Wick



Images hosted on other servers:

Enlarged erythematous breast

Microscopic (histologic) description
  • Usually dermal plugging of lymphatics by tumor, may not be seen in small biopsies
  • No specific histology, although usually high grade ductal NOS
Microscopic (histologic) images

AFIP images

Tumor in dermal lymphatics


Contributed by Weijie Li, M.D.



Images hosted on other servers:

Tumor in dermal lymphatics

Tumor embolus in a dermal lymphatic channel

E-cadherin+

Positive stains
Differential diagnosis
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