Breast malignant, males, children
Intralymphatic breast carcinoma
Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 10 October 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Extensive intralymphatic component with no (pure intralymphatic carcinoma) or only minimal (predominantly pure intralymphatic carcinoma) residual invasive carcinoma (Am J Surg Pathol 2009;33:256)
● Clinically significant pattern of residual disease post chemotherapy; associated with post-chemotherapy nodal metastases
● Presence of residual intralymphatic tumor is associated with increased mortality
● Pure cases may have no gross findings
● Pure cases have no invasive disease
● Predominantly pure cases have minimal invasive disease
● D2-40 is helpful to identify lymphatics, although it also stains myoepithelium, particularly in solid DCIS and LCIS
(Hum Pathol 2008;39:175)
● E-cadherin is associated with lymphovascular invasion (Cancer 2003;97:2341)
● Metastatic ovarian serous carcinoma
(Breast J 2009;15:176)
End of Breast malignant, males, children > Carcinoma subtypes > Intralymphatic breast carcinoma
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