Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Breast malignant, males, children

Carcinoma subtypes

Intralymphatic breast carcinoma


Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 10 October 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

See also angiolymphatic invasion, inflammatory carcinoma

● Extensive intralymphatic component with no (pure intralymphatic carcinoma) or only minimal (predominantly pure intralymphatic carcinoma) residual invasive carcinoma (Am J Surg Pathol 2009;33:256)

Clinical description
=========================================================================

● Clinically significant pattern of residual disease post chemotherapy; associated with post-chemotherapy nodal metastases

Treatment
=========================================================================

● Presence of residual intralymphatic tumor is associated with increased mortality

Gross description
=========================================================================

● Pure cases may have no gross findings

Micro description
=========================================================================

● Pure cases have no invasive disease
● Predominantly pure cases have minimal invasive disease

Positive stains
=========================================================================

● D2-40 is helpful to identify lymphatics, although it also stains myoepithelium, particularly in solid DCIS and LCIS (Hum Pathol 2008;39:175)
● E-cadherin is associated with lymphovascular invasion (Cancer 2003;97:2341)

Differential diagnosis
=========================================================================

● Metastatic ovarian serous carcinoma (Breast J 2009;15:176)

End of Breast malignant, males, children > Carcinoma subtypes > Intralymphatic breast carcinoma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).