Intralymphatic breast carcinoma

Breast malignant, males, children
Carcinoma subtypes
Intralymphatic breast carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 December 2016, last major update August 2012

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PubMed search: intralymphatic breast carcinoma

Table of Contents

Cite this page: Intralymphatic breast carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantintralymphatic.html. Accessed July 14th, 2017.

Definition / general

Extensive intralymphatic component with no (pure intralymphatic carcinoma) or only minimal (predominantly pure intralymphatic carcinoma) residual invasive carcinoma (Am J Surg Pathol 2009;33:256)
See also angiolymphatic invasion, inflammatory carcinoma

Clinical features

Clinically significant pattern of residual disease post chemotherapy; associated with post chemotherapy nodal metastases

Treatment

Presence of residual intralymphatic tumor is associated with increased mortality

Gross description

Pure cases may have no gross findings

Microscopic (histologic) description

Pure cases have no invasive disease
Predominantly pure cases have minimal invasive disease

Positive stains

D2-40 is helpful to identify lymphatics, although it also stains myoepithelium, particularly in solid DCIS and LCIS (Hum Pathol 2008;39:175)
E-cadherin is associated with lymphovascular invasion (Cancer 2003;97:2341)

Differential diagnosis

Metastatic ovarian serous carcinoma (Breast J 2009;15:176)