Breast malignant, males, children
Childhood tumors
Juvenile fibroadenoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 27 December 2016, last major update August 2012

Copyright: (c) 2001-2016, PathologyOutlines.com, Inc.

PubMed Search: juvenile fibroadenoma
Cite this page: Juvenile fibroadenoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantjuvenilefibroadenoma.html. Accessed April 28th, 2017.
Terminology
  • Also called giant fibroadenoma
  • Not a distinct entity in WHO breast classification
Epidemiology
  • Usually adolescents, often African American, often bilateral and with rapid growth to > 10 cm
Clinical features
  • May have atypical ductal hyperplasia suggestive of DCIS - low risk of carcinoma, but followup is recommended (Am J Surg Pathol 1987;11:184)
Prognostic factors
Case reports
Treatment
Clinical images

Images hosted on other servers:

Various images

Gross images

Images hosted on other servers:

Various images

Bilateral giant juvenile fibroadenoma

Gray-white mass (fig 4)

Microscopic (histologic) description
  • Stromal and epithelial hyperplasia, but no stromal atypia and no / rare stromal mitotic figures
  • No periductal increase in cellularity, no stromal overgrowth, no cytologic atypia, mitotic rate < 3 / HPF (Stanford University)
Microscopic (histologic) images

Images hosted on other servers:

Stromal and epithelial hyperplasia


Bilateral giant juvenile fibroadenoma

Various images

Cytology images

Images hosted on other servers:

Cluster of epithelial cells with mild pleomorphism

Epithelial cells and stromal fragments with few spindled cells

Branching sheets of epithelial
cells with many bare nuclei and
myxoid stromal fragments

Differential diagnosis