Breast malignant, males, children
Childhood tumors
Juvenile papillomatosis (swiss cheese disease)

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 27 December 2016, last major update August 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: juvenile papillomatosis
Cite this page: Juvenile papillomatosis (swiss cheese disease). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantjuvenilepapillomatosis.html. Accessed February 24th, 2017.
Definition / General
  • Grossly distinct multinodular mass with clustering of cystic formations resembling swiss cheese, composed of epithelial proliferation and clustered cysts
  • First described by Rosen in 1980 (Am J Surg Pathol 1980;4:3)
Terminology
  • Not part of WHO breast classification
Epidemiology
  • Mean age 19 years
  • 2 / 3 are less than age 20 years
Clinical Features
Case Reports
Clinical Images

Images hosted on PathOut server:

Mammogram, courtesy of Dr. Mark R. Wick

Gross Description
  • Localized multinodular mass with clustering of cystic formations resembling swiss cheese
Gross Images

Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Multiple cysts resembling swiss cheese

Micro Description
  • Florid epithelial hyperplasia and papillomatosis, cysts with foamy histiocytes and sclerosing adenosis
  • Variable apocrine metaplasia, atypia and necrosis
Micro Images

Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick



AFIP images:

Multiple cystically dilated ducts

Hyperplastic epithelium in dilated duct

Intraductal epithelial proliferation with necrosis

Apocrine metaplasia
of hyperplastic
intraductal epithelium


Hyperplastic epithelium and foam cells

With sclerosing
adenosis and
apocrine metaplasia
adjacent to cystically
dilated ducts

Multiple small intraductal papillomas in 15 year old girl

#2 - high power shows hyperplastic
intraductal epithelium, myoepithelial cells are
associated with the delicate fibrovascular stalks



Images hosted on other servers:

Missing Image

Various images

Clustered cysts

Epithelial hyperplasia

Cytology Description
  • Difficult to diagnose
  • Cystic fluid, but mass persists after aspiration
  • Sheets of hyperplastic breast epithelium with areas resembling fibroadenoma, macrophages and apocrine cells (Diagn Cytopathol 1993;9:457)