Invasive breast carcinoma of no special type and variants
Lipid rich

Topic Completed: 1 October 2012

Minor changes: 21 June 2020

Copyright: 2001-2019,, Inc.

PubMed search: lipid rich carcinoma breast

Monika Roychowdhury, M.D.
Page views in 2019: 1,436
Page views in 2020 to date: 1,749
Cite this page: Roychowdhury M. Lipid rich. website. Accessed November 23rd, 2020.
Definition / general
  • 90%+ cells have prominent intracytoplasmic neutral lipid
Clinical features
  • 1% - 2% of breast carcinomas
  • Axillary metastases may resemble histiocytes
Prognostic factors
  • Poor prognosis due to frequent (70%) nodal metastases at presentation
Case reports
Gross description
  • Lobulated, variable circumscription, firm
  • 1 to 15 cm
Microscopic (histologic) description
  • Nests, cords and sheets of large polygonal cells with foamy or vacuolated cytoplasm containing lipid
  • May resemble clear cells or lipoblasts
  • Irregular nuclei with coarse chromatin, moderate atypia, prominent nucleoli
  • Other patterns are large pleomorphic cells in alveolar pattern with hobnail appearance, oncocytic or apocrine type change
Microscopic (histologic) images

AFIP images

Polygonal tumor cells
with distinct cell
borders and variable
cytoplasmic clearing

Images hosted on other servers:

Fig 1: tumor with pushing borders and lymphoplasmacytic and eosinophilic infiltrate (arrow: high grade comedo DCIS)
Fig 2: tumor composed of sheets and cords of large polyhedral
cells with ill defined borders, fine granular, eosinophilic cytoplasm and large nuclei with prominent nucleoli and coarse chromatin
Fig 3: also large clear cells with foamy or vacuolated cytoplasm
Fig 4: axillary nodal metastasis

Positive stains
Negative stains
Electron microscopy description
Electron microscopy images

AFIP images

Luminal microvilli, lipid droplets and mitochondria

Differential diagnosis
Additional references
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