Breast malignant, males, children
Carcinoma subtypes
Lipid rich carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 December 2016, last major update October 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: lipid rich carcinoma breast

Cite this page: Lipid rich carcinoma. website. Accessed June 18th, 2018.
Definition / general
  • 90%+ cells have prominent intracytoplasmic neutral lipid
Clinical features
  • 1% - 2% of breast carcinomas
  • Axillary metastases may resemble histiocytes
Prognostic factors
  • Poor prognosis due to frequent (70%) nodal metastases at presentation
Case reports
Gross description
  • Lobulated, variable circumscription, firm
  • 1 to 15 cm
Microscopic (histologic) description
  • Nests, cords and sheets of large polygonal cells with foamy or vacuolated cytoplasm containing lipid
  • May resemble clear cells or lipoblasts
  • Irregular nuclei with coarse chromatin, moderate atypia, prominent nucleoli
  • Other patterns are large pleomorphic cells in alveolar pattern with hobnail appearance, oncocytic or apocrine type change
Microscopic (histologic) images
Images hosted on PathOut server:

Polygonal tumor cells
with distinct cell borders
and variable cytoplasmic
clearing (AFIP)

Images hosted on other servers:

Fig 1: tumor with pushing borders and lymphoplasmacytic and eosinophilic infiltrate (arrow: high grade comedo DCIS)
Fig 2: tumor composed of sheets and cords of large polyhedral
cells with ill defined borders, fine granular, eosinophilic cytoplasm and large nuclei with prominent nucleoli and coarse chromatin
Fig 3: also large clear cells with foamy or vacuolated cytoplasm
Fig 4: axillary nodal metastasis

Positive stains
Negative stains
Electron microscopy description
Electron microscopy images
Images hosted on PathOut server:

Luminal microvilli, lipid droplets and mitochondria

Differential diagnosis
Additional references