Breast malignant, males, children
Carcinoma subtypes
Lobular carcinoma - alveolar variant

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 October 2016, last major update August 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Alveolar variant of lobular carcinoma

Cite this page: Lobular carcinoma - alveolar variant. website. Accessed April 20th, 2018.
Clinical features
Case reports
Microscopic (histologic) description
  • Sharply outlined (rounded) groups or nests of 20 or more cells, resembling alveoli, separated by delicate fibrovascular tissue
  • May have osteoclast giant cells (Pathologica 1993;85:525)
Microscopic (histologic) images

Images hosted on PathOut server:

Tumor cells in discrete
rounded aggregates separated
by fibrous stroma (AFIP)

Images hosted on other servers:

Uniform alveolar growth pattern

E-cadherin negative

Cytology description
Electron microscopy description
  • Tumor cells are similar to classic lobular tumors, but nests of cells are surrounded by elongated fibroblasts or myofibroblasts (Ultrastruct Pathol 1986;10:311)
Differential diagnosis
  • Lobular carcinoma in situ: groups of cells have distinct myoepithelial layer and basement membrane
  • Lymphoma: negative for epithelial markers, positive for lymphocytic markers