Breast malignant, males, children
Carcinoma subtypes
Lobular carcinoma - alveolar variant

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 October 2016, last major update August 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Alveolar variant of lobular carcinoma

Cite this page: Lobular carcinoma - alveolar variant. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantlobularalveolar.html. Accessed December 9th, 2016.
Clinical Features
Case Reports
Micro Description
  • Sharply outlined (rounded) groups or nests of 20 or more cells, resembling alveoli, separated by delicate fibrovascular tissue
  • May have osteoclast giant cells (Pathologica 1993;85:525)
Micro Images

Images hosted on PathOut server:

Tumor cells in discrete
rounded aggregates separated
by fibrous stroma (AFIP)



Images hosted on other servers:

Uniform alveolar growth pattern

E-cadherin negative

Cytology Description
Electron Microscopy Description
  • Tumor cells are similar to classic lobular tumors, but nests of cells are surrounded by elongated fibroblasts or myofibroblasts (Ultrastruct Pathol 1986;10:311)
Differential Diagnosis
  • Lobular carcinoma in situ: groups of cells have distinct myoepithelial layer and basement membrane
  • Lymphoma: negative for epithelial markers, positive for lymphocytic markers