Breast malignant, males, children
Alveolar variant of lobular carcinoma
Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 29 October 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● 4-15% of infiltrating lobular carcinoma cases
(Br J Cancer 1989;60:605, Breast Cancer Res Treat 2012;133:713)
● Often postmenopausal women (Am J Clin Pathol 1986;85:1)
● May have poorer prognosis than classic lobular carcinoma (Cancer 2008;113:1511)
● 74 year old woman with synchronous classic and alveolar lobular carcinomas (Am J Surg Pathol 2011;35:1743)
● Sharply outlined (rounded) groups or nests of 20 or more cells, resembling alveoli, separated by delicate fibrovascular tissue
● May have osteoclast giant cells (Pathologica 1993;85:525)
Uniform alveolar growth pattern
Tumor cells in discrete rounded aggregates separated by fibrous stroma (AFIP)
May have retained E-cadherin staining (fig d/e)
● Rosette like pattern
(Acta Cytol 2000;44:169)
● Tumor cells are similar to classic lobular tumors, but nests of cells are surrounded by elongated fibroblasts or myofibroblasts
(Ultrastruct Pathol 1986;10:311)
● Lobular carcinoma in situ - groups of cells have distinct myoepithelial layer and basement membrane
● Lymphoma - negative for epithelial markers, positive for lymphocytic markers
End of Breast malignant, males, children > Carcinoma subtypes > Alveolar variant of lobular carcinoma
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