Breast malignant, males, children - Basal-like variant of invasive lobular carcinoma

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Breast malignant, males, children

Carcinoma subtypes

Basal-like variant (subset) of invasive lobular carcinoma

Reviewer: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 29 October 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Clinical description
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● Invasive lobular carcinoma cases include all molecular subtypes, include basal-like, and basal-like carcinomas include a variety of histologic subtypes (J Pathol 2008;216:141)
● CK5/6 positivity, part of definition of basal-like tumors, is present in 17% of lobular tumors (Hum Pathol 2008;39:331)
● Associated with grade 3 tumors (50%) and ER negativity, but similar morphology otherwise

Negative stains
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● E-cadherin

End of Breast malignant, males, children > Carcinoma subtypes > Basal-like variant (subset) of invasive lobular carcinoma

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