Advertisement
Advertisement
Table of Contents
Definition / general | Terminology | Clinical features | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Lobular carcinoma - histiocytoid variant. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantlobularhistiocytoid.html. Accessed July 14th, 2017.
Definition / general
- Diffuse growth of tumor cells with abundant granular, foamy (vacuolated) cytoplasm and small bland nuclei
- First described by Hood et al (Cancer 1973;31:793)
Terminology
- Also called myoblastomatoid variant of lobular carcinoma
Clinical features
- Metastases may appear before diagnosis of primary tumor
- May metastasize to eyelid
- May be a variant of apocrine carcinoma (Am J Surg Pathol 1995;19:553)
Case reports
- 68 year old man with 2.5 cm mass (Ann Diagn Pathol 2011;15:190)
- 93 year old woman with erythematous breast (Arch Pathol Lab Med 2003;127:1626)
- Histiocytoid metastases at autopsy (Arch Pathol Lab Med 1986;110:759)
- Triple negative case (Breast J 2010;16:84)
Microscopic (histologic) description
- Diffuse growth of tumor cells with abundant granular, foamy (vacuolated) cytoplasm and small bland nuclei
- Resembles histiocytes or granular cell tumor
Microscopic (histologic) images
Images hosted on PathOut server:
Tumor cells have abundant cytoplasm
and vesicular nuclei, resembling histiocytes
Images hosted on other servers:
Tumor cells have abundant cytoplasm and vesicular nuclei, resembling histiocytes
Figures 1-2: H&E and stains
Fig A: LCIS (arrows) and large cells in single file with focal targetoid growth, inset
Fig B: finely granular pale pink cytoplasm; inset: intracytoplasmic lumina
Fig C: tumor infiltration of fat mimics fat necrosis, inset: GCDFP-15+
Fig D: E-Cadherin in LCIS and invasive tumor
Cytology description
- Loosely cohesive tumor cells with abundant foamy to granular cytoplasm and bland nuclei (Pathol Int 2005;55:353)
Differential diagnosis
- Granular cell tumor: PAS+ cytoplasmic granules
- Histiocytoma: no atypia, histiocytes are CD68+, keratin-
- Lipid rich carcinoma: infiltrating ductal carcinoma with lipid in tumor cytoplasm, no mucin, very rare
- Xanthelasma: lipid filled cells, often in eyelid
- Xanthoma: no atypia
Additional references
Advertisement
