Breast malignant, males, children
Carcinoma subtypes
Lobular carcinoma - histiocytoid variant

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 October 2016, last major update August 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Histiocytoid variant of lobular carcinoma

Cite this page: Lobular carcinoma - histiocytoid variant. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantlobularhistiocytoid.html. Accessed December 4th, 2016.
Definition / General
  • Diffuse growth of tumor cells with abundant granular, foamy (vacuolated) cytoplasm and small bland nuclei
  • First described by Hood et al (Cancer 1973;31:793)
Terminology
  • Also called myoblastomatoid variant of lobular carcinoma
Clinical Features
  • Metastases may appear before diagnosis of primary tumor
  • May metastasize to eyelid
  • May be a variant of apocrine carcinoma (Am J Surg Pathol 1995;19:553)
Case Reports
Micro Description
  • Diffuse growth of tumor cells with abundant granular, foamy (vacuolated) cytoplasm and small bland nuclei
  • Resembles histiocytes or granular cell tumor
Micro Images

Images hosted on PathOut server:

Tumor cells have abundant cytoplasm
and vesicular nuclei, resembling histiocytes



Images hosted on other servers:

Tumor cells have abundant cytoplasm and vesicular nuclei, resembling histiocytes

Figures 1-2: H&E and stains



Fig A: LCIS (arrows) and large cells in single file with focal targetoid growth, inset
Fig B: finely granular pale pink cytoplasm; inset: intracytoplasmic lumina
Fig C: tumor infiltration of fat mimics fat necrosis, inset: GCDFP-15+
Fig D: E-Cadherin in LCIS and invasive tumor

Cytology Description
  • Loosely cohesive tumor cells with abundant foamy to granular cytoplasm and bland nuclei (Pathol Int 2005;55:353)
Positive Stains
Negative Stains
Differential Diagnosis