Breast malignant, males, children - Solid variant of lobular carcinoma

Home Chapter Home Jobs Conferences Fellowships Books

Breast malignant, males, children

Carcinoma subtypes

Solid variant of lobular carcinoma

Reviewer: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 15 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● First described in 1975 (Hum Pathol 1975;6:373)
● Cells grow in sheets that engulf normal structures and infiltrate fat, but have cytologic features of classic lobular carcinoma
● Little intervening stroma present
● Resembles lymphoma

Clinical features
=========================================================================

● In 1989, represented 6% of all lobular carcinomas, and had poorest survival of all subtypes (Br J Cancer 1989;60:605)

Case reports
=========================================================================

● Resembling non-Hodgkin's lymphoma (Acta Cytol 1994;38:767)

Micro images
=========================================================================

Diffuse tumor cell infiltration

Solid pattern, but cells are still separate and distinct

Pan-keratin

E-cadherin

Differential diagnosis
=========================================================================

● Histiocytoid variant of lobular carcinoma: solid growth pattern, but with foamy to granular cytoplasmic change (Pathol Int 2005;55:353)

End of Breast malignant, males, children > Carcinoma subtypes > Solid variant of lobular carcinoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).