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Breast malignant, males, children

Carcinoma subtypes

Solid variant of lobular carcinoma


Reviewer: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 15 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● First described in 1975 (Hum Pathol 1975;6:373)
● Cells grow in sheets that engulf normal structures and infiltrate fat, but have cytologic features of classic lobular carcinoma
● Little intervening stroma present
● Resembles lymphoma

Clinical features
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● In 1989, represented 6% of all lobular carcinomas, and had poorest survival of all subtypes (Br J Cancer 1989;60:605)

Case reports
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● Resembling non-Hodgkin's lymphoma (Acta Cytol 1994;38:767)

Micro images
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Diffuse tumor cell infiltration

   
Solid pattern, but cells are still separate and distinct


Pan-keratin


E-cadherin

Differential diagnosis
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Histiocytoid variant of lobular carcinoma: solid growth pattern, but with foamy to granular cytoplasmic change (Pathol Int 2005;55:353)

End of Breast malignant, males, children > Carcinoma subtypes > Solid variant of lobular carcinoma


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