Breast malignant, males, children
Other malignancies
Lymphoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 29 December 2016, last major update August 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: breast lymphoma
Cite this page: Lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantlymphoma.html. Accessed August 19th, 2017.
Definition / general
  • Criteria for primary breast lymphoma: (a) sufficient tissue for diagnosis; (b) close interaction between lymphoma infiltrate and breast tissue; (c) no evidence of widespread lymphoma at time of diagnosis; (d) no prior diagnosis of nonbreast lymphoma (Cancer 1972;29:1705)
  • Secondary breast lymphoma has similar incidence as primary breast lymphoma and is most common metastatic disease to breast
  • 94% B-cell and 4% T-cell lymphomas in one study (Br J Radiol 2012;85:e195)

  • Anaplastic large cell lymphoma:
  • Burkitt's lymphoma:
    • In African patients, may present with massive bilateral breast involvement
    • Patients may be pregnant or lactating
    • Less common than other subtypes

  • Diffuse large B-cell lymphoma:
  • Follicular lymphoma: usually stage I (65%), but 20% are stage III / IV

  • Marginal zone / MALT lymphoma:
Epidemiology
  • Rare, < 1% of all breast malignancies are primary breast lymphoma
  • Usually ages 30 - 35 years (diffuse large B-cell) or 55 - 60 years (diffuse large B-cell or MALT-type)
  • Screening mammography may be increasing detection of low grade lymphoma
  • No association between implants and lymphoma (Plast Reconstr Surg 2009;123:790), but see anaplastic lymphoma below
Prognostic factors
Case reports
Treatment
Clinical images

Images hosted on PathOut server:


Contributed by Dr. Mark R. Wick:

Mammogram, large cell

Mammogram, lymphoblastic

Large cell

Large cell, breast skin

Gross description
  • Soft, gray-white
  • 25% bilateral
  • No skin retraction, no nipple discharge
Gross images

Images hosted on PathOut server:

Large cell, parenchyma, contributed by Dr. Mark R. Wick

Microscopic (histologic) description
Microscopic (histologic) images

Scroll to see all images.


Images hosted on PathOut server:


Anaplastic large cell lymphoma, contributed by Dr. Mark R. Wick:

H&E, ALK1, CD30



Burkitt's lymphoma:

PAX5 stain, contributed by Dr. Mark R. Wick



CLL / SLL, contributed by Dr. Julia Braza, Beth Israel Deaconness Medical Center, Boston, Massachusetts:

X-ray, H&E, CD5, CD20



Diffuse large B-cell, contributed by Dr. Mark R. Wick:

Parenchyma

Green pyronine



Follicular lymphoma:

Bulging and fleshy tumor

Contributed by Dr. Mark R. Wick



Lymphoblastic lymphoma, contributed by Dr. Mark R. Wick:

CD10

TdT



Marginal zone / MALT lymphoma, contributed by Dr. Mark R. Wick:



Plasmablastic lymphoma:

HIV+, contributed by Dr. Mark R. Wick



T-cell Lymphoma, contributed by Dr. Mark R. Wick:

Panniculitis-like

Panniculitis-like, parenchymamic




Images hosted on other servers:


Anaplastic large cell lymphoma:

Associated with silicon implant

Various images


Sarcomatoid variant

ALK neg cases



Burkitt's lymphoma:

Various images



Diffuse large B-cell lymphoma:

Rapidly growing mass

H&E and CD20

Various images



Follicular lymphoma:

Follicular lymphoma

BCL2+



Mantle cell lymphoma:

Various images



Marginal zone / MALT lymphoma:

H&E, CD20, BCL10



NK lymphoma, nasal type:

Lobular pattern of infiltration



Peripheral T-cell lymphoma:

CD8+ tumor

Abundant cytoplasm and atypia

Cytology images

Images hosted on PathOut server:


Contributed by Dr. Mark R. Wick:

Large cell (Diff Quik)

Lymphoblastic, parenchyma

Positive stains
  • CD45, B-cell or T-cell markers
  • Other markers vary by subtype
Negative stains
  • Keratin (may stain lymphoepithelial lesions)
Differential diagnosis