Breast malignant, males, children
Male tumors
Male breast carcinoma - General

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 22 December 2016, last major update August 2012

Copyright: (c) 2001-2016,, Inc.

PubMed Search: male breast carcinoma
Cite this page: Male breast carcinoma - General. website. Accessed February 20th, 2018.
  • Very rare
  • Have higher risk for second primary (breast, stomach and melanoma, Breast Cancer Res 2007;9:R10)
  • In U.S., males have 1% the rate of breast carcinoma of women; 1000 - 1500 new cases per year in U.S.
  • Mean age 60 years at diagnosis
  • Histology similar to women, mostly ductal and most ER+
  • Incidence may be increasing in U.S., Canada and U.K. (World J Surg Oncol 2008;6:58)
Risk factors
Clinical features
  • Typically firm, painless mass in subareolar breast or upper, outer quadrant
  • Nipple discharge in men is strongly suggestive
  • Often presents at high stage since minimal breast substance (Saudi Med J 2009;30:1060)
  • Axillary nodes in 50% at presentation
  • Luminal A and B subtypes are most common (Breast Cancer Res 2009;11:R28)
Prognostic factors
Case reports
Gross images

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Intracystic papillary carcinoma

Microscopic (histologic) description
  • Similar to female tumors
  • Invasive ductal carcinoma is most common, papillary is #2 (Virchows Arch 2006;449:507); invasive lobular / LCIS is rare
Microscopic (histologic) images

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Images hosted on PathOut server:

AFIP images:

DCIS solid type after estrogen for prostate cancer

Invasive carcinoma with cribriform pattern

Intracystic papillary carcinoma

Cystic papillary carcinoma with invasion

Images hosted on other servers:

DCIS, various

DCIS and invasive carcinoma

Androgen receptor+


Invasive ductal carcinoma (A), solid papillary carcinoma (B)

Intracystic papillary DCIS

Nodal metastases



Luminal B tumor

Various subtypes

Intracystic papillary carcinoma

Gynecomastia with chemoradiation induced atypia

Man with adenoid cystic carcinoma

Cytology description
  • Reliable but underutilized (Acta Cytol 2009;53:369)
  • Papillary tumors:
    • Papillary clusters of epithelial cells with variable fibrovascular cores
    • Also single epithelial cells with high N / C ratio and eccentric nuclei, hemosiderin-laden macrophages (Cancer 2006;108:222)
Positive stains
Negative stains
Differential diagnosis
Additional references