Breast malignant, males, children - Metastases to male breast

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Breast malignant, males, children

Male tumors

Metastases to male breast

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 18 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Clinical features
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● 2% of all nonhematologic breast malignancies
● Most common primary is melanoma; also prostate (Urology 1978;11:641), colon, lung and bladder (Virchows Arch 2006;449:507)
● Prostate metastases are often bilateral, usually after estrogen therapy in background of gynecomastia; PSA+, PAP+ (note that the normal male breast and gynecomastia may be PSA+ but PAP-, Breast Cancer Res 2004;6:R18, Hum Pathol 1991;22:242)
● Need strong index of suspicious to diagnose, may need immunostains to distinguish primary and metastatic disease

Radiology
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● Single, round, discrete lesions without spiculation (Acta Cytol 2002;46:377)

Case reports
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Primaries from:
● Bladder (Br J Radiol 2000;73:1326)
● Lung (Australas Radiol 1998;42:16, South Med J 2007;100:850)
● Prostate (Hinyokika Kiyo 1999;45:269, Arch Pathol Lab Med 2001;125:1101)
● Skin eccrine adenocarcinoma (J Cutan Pathol 2007;34:934)

Micro description
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● Usually no DCIS or elastosis (J Clin Pathol 2007;60:1333)

Micro images
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Prostatic carcinoma metastases to male papillary breast cancer

Prostate primary

End of Breast malignant, males, children > Male tumors > Metastases to male breast

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