Breast malignant, males, children
Carcinoma subtypes
Metastases to breast

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 29 December 2016, last major update October 2012

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PubMed search: carcinoma [title] "metastases" to breast

Cite this page: Metastases to breast. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantmet.html. Accessed May 25th, 2017.
Definition / general
Clinical features
  • Rare (1% - 2% of breast tumors), usually from contralateral breast (Arch Pathol Lab Med 2008;132:931)
  • Also lung, melanoma, ovary, kidney, stomach and thyroid (World J Surg Oncol 2007;5:74)
  • Usually occurs in patients with advanced disease
  • In children, rhabdomyosarcoma (alveolar variant) is most common metastasis to breast
Case reports
Gross description
  • Often superficial (in soft tissue), well circumscribed firm nodules without skin retraction or peau d’orange
Gross images
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Colonic adenocarcinoma

Microscopic (histologic) description
  • Most important feature is that it does not resemble a primary breast carcinoma
  • Usually no ductal carcinoma in situ (DCIS), although infiltrative pattern may resemble DCIS (Ann Diagn Pathol 2001;5:15)

Metastatic ovarian or peritoneal serous carcinoma to breast or axilla:
Microscopic (histologic) images
Images hosted on PathOut server:

Various images

Small intestinal carcinoid - chromogranin+



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Choriocarcinoma: antibody to hCG

Colonic adenocarcinoma

Lung: neuroendocrine carcinoma

Chromogranin+


Synaptophisin+

Renal cell carcinoma

Small intestinal carcinoid

Infiltrating nests of tumor within small intestinal wall

Cytology images
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Left: medulloblastoma; right: melanoma

Negative stains