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Table of Contents
Definition / general | Clinical features | Case reports | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Electron microscopy images | Differential diagnosis | Additional referencesCite this page: Metaplastic carcinoma - fibromatosis-like. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantmetaplasticfibro.html. Accessed July 14th, 2017.
Definition / general
- Variant of metaplastic carcinoma resembling fibromatosis with propensity for local recurrence
- First described in 1999 (Cancer 1999;85:2170)
- A basal-like tumor with a favorable clinical outcome (Tumori 2009;95:264)
Clinical features
- Mean age 65 years (range, 40 - 85 years)
- May recur locally or have distant metastases (Am J Surg Pathol 2001;25:1009), usually no nodal metastases
Case reports
- 59 year old woman with a spindle cell lesion of the breast (Arch Pathol Lab Med 2006;130:e81)
- 74 year old woman with a 2.5 cm, palpable breast nodule (Acta Cytol 2010;54:712)
- 77 year old woman with a 2 x 2 cm mass with irregular margins in the upper and outer quadrant of left breast (World J Surg Oncol 2007;5:24)
Gross description
- Mean 3 cm (1 - 7 cm), well defined borders
Microscopic (histologic) description
- Fibromatosis-like or myofibroblastic-like growth pattern of bland spindle cells in prominent collagenous stroma, infiltrative borders, usually inflammatory infiltrate
- < 5% of tumor is composed of carcinoma or epithelial elements
- Low mitotic activity (Cesk Patol 2002;38:164)
Microscopic (histologic) images
Images hosted on other servers:
Various images
Fig 1: rare nests of bland epithelial cells with focal squamous metaplasia (inset)
Fig 2: rare mitotic figures
Fig 3: keratin+ and smooth muscle actin+ spindle cells
Fig 4: p63+ spindle cells
Positive stains
- Cytokeratin for epithelial elements (high molecular weight subtypes), p63, smooth muscle actin (usually only in keratin negative cells)
Electron microscopy images
Images hosted on other servers:
Single cell with peripheral villous
processes in collagenous stroma Inset
shows tumor cell cluster with microvilli
and cell junctions (arrow)
Differential diagnosis
Benign or malignant spindle cell lesions (keratin negative) including:
Additional references
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