Metaplastic carcinoma

Topic Completed: 1 September 2012

Minor changes: 21 June 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Fibromatosis like variant of metaplastic carcinoma

Monika Roychowdhury, M.D.
Page views in 2019: 1,451
Page views in 2020 to date: 1,904
Cite this page: Roychowdhury M. fibromatosis-like. website. Accessed November 25th, 2020.
Definition / general
  • Variant of metaplastic carcinoma resembling fibromatosis with propensity for local recurrence
  • First described in 1999 (Cancer 1999;85:2170)
  • A basal-like tumor with a favorable clinical outcome (Tumori 2009;95:264)
Clinical features
  • Mean age 65 years (range, 40 - 85 years)
  • May recur locally or have distant metastases (Am J Surg Pathol 2001;25:1009), usually no nodal metastases
Case reports
Gross description
  • Mean 3 cm (1 - 7 cm), well defined borders
Microscopic (histologic) description
  • Fibromatosis-like or myofibroblastic-like growth pattern of bland spindle cells in prominent collagenous stroma, infiltrative borders, usually inflammatory infiltrate
  • < 5% of tumor is composed of carcinoma or epithelial elements
  • Low mitotic activity (Cesk Patol 2002;38:164)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Fig 1: rare nests of bland epithelial cells with focal squamous metaplasia (inset)
Fig 2: rare mitotic figures
Fig 3: keratin+ and smooth muscle actin+ spindle cells
Fig 4: p63+ spindle cells

Positive stains
Negative stains
Electron microscopy images

Images hosted on other servers:

Single cell with peripheral villous
processes in collagenous stroma Inset
shows tumor cell cluster with microvilli
and cell junctions (arrow)

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Image 01 Image 02