Breast malignant, males, children

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Breast malignant, males, children

In situ carcinoma

Micropapillary DCIS

Reviewer: Dina Kandil, M.D. (see Reviewers page)
Revised: 8 November 2012, last major update January 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Gross
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● 25% of cases involve multiple quadrants of breast (multicentric)

Micro description
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● Tufts of proliferating epithelial cells projecting into the ductal lumen, without fibrovascular cores, characteristic of true papillary lesions
● These micropapillae are narrow at the base and have bulbous expansion at the tip resembling a club
● Tips of epithelial tufts may fuse together, forming “bridges” and “arcades”
● Cells are uniform and evenly distributed
● Usually low grade DCIS without necrosis
● Can be associated with flat epithelial atypia (Mod Pathol 2007;20:1149)

Micro images
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Various images


No true fibrovascular cores

Roman bridges


Within a papilloma


Apocrine features

With cribriform DCIS

With hypersecretory features


With columnar cell change

Discontinuous fragments related to plane of sectioning

Micropapillae lack fibrovascular cores, cells are homogeneous

Cytology images
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Nipple discharge shows high nuclear grade micropapillary DCIS (Giemsa stain)

End of Breast malignant, males, children > In situ carcinoma > Micropapillary DCIS

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