Breast malignant, males, children
In situ carcinoma
Reviewer: Dina Kandil, M.D. (see Reviewers page)
Revised: 8 November 2012, last major update January 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● 25% of cases involve multiple quadrants of breast (multicentric)
● Tufts of proliferating epithelial cells projecting into the ductal lumen, without fibrovascular cores, characteristic of true papillary lesions
● These micropapillae are narrow at the base and have bulbous expansion at the tip resembling a club
● Tips of epithelial tufts may fuse together, forming “bridges” and “arcades”
● Cells are uniform and evenly distributed
● Usually low grade DCIS without necrosis
● Can be associated with flat epithelial atypia (Mod Pathol 2007;20:1149)
No true fibrovascular cores
Within a papilloma
With cribriform DCIS
With hypersecretory features
With columnar cell change
Discontinuous fragments related to plane of sectioning
Micropapillae lack fibrovascular cores, cells are homogeneous
Nipple discharge shows high nuclear grade micropapillary DCIS (Giemsa stain)
End of Breast malignant, males, children > In situ carcinoma > Micropapillary DCIS
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