Breast malignant, males, children - Malignant Peripheral Nerve Sheath Tumor (MPNST)

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Breast malignant, males, children

Sarcoma

Malignant Peripheral Nerve Sheath Tumor (MPNST)

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 7 November 2012, last major update November 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Definition
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● Very rare in breast
● Most cases are not associated with neurofibromatosis

Terminology
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● Not part of WHO breast classification

Case reports
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● 19 year old woman (J Med Assoc Thai 2006;89:377)
● 38 year old woman (World J Surg Oncol 2007;5:142)
● 56 year old woman with 30 cm tumor (Br J Radiol 2007;80:e44)

Gross images
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30 cm tumor

Micro images
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Alternating hyper and hypocellular areas with palisading spindle shaped cells and intervening myxoid areas; cells are S100+ (inset)

Hyperchromatic and pleomorphic wavy nuclei with mitoses

End of Breast malignant, males, children > Sarcoma > Malignant Peripheral Nerve Sheath Tumor (MPNST)

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