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Breast malignant, males, children

In situ carcinoma

Mucinous DCIS

Reviewer: Dina Kandil, M.D. (see Reviewers page)
Revised: 14 January 2012, last major update January 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● DCIS with extracellular mucin production
● Mucin is usually in lumens of ducts involved by DCIS; also in vessels
● There are few studies of this entity (Histopathology 1996;29:533)


● Mean age 62 years
● Predominant histologic types are solid, cribriform and micropapillary
● DCIS grading - low grade/1 (29%), intermediate grade/2 (61%), high grade/3 (10%)


● Often associated with neovascularization in intraluminal mucin, although the presence of vascularized mucin in a needle biopsy cannot differentiate between in situ and invasive disease (Histopathology 2008;53:545)

Micro images

DCIS (micropapillary) with invasive mucinous carcinoma

Differential diagnosis

Invasive mucinous carcinoma: mucin is in direct contact with stroma, and tumor cells are floating in mucin

End of Breast malignant, males, children > In situ carcinoma > Mucinous DCIS

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