Breast malignant, males, children - Mucoepidermoid carcinoma

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Breast malignant, males, children

Carcinoma subtypes

Mucoepidermoid carcinoma

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 6 October 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Terminology
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● See also adenosquamous carcinoma; also called adenoacanthoma

Clinical features
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● Very rare
● Grading system used for salivary gland tumors is recommended (Virchows Arch 2004;444:13)

Case reports
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● 46 year old woman with high grade tumor and axillary metastases (Arch Pathol Lab Med 1981;105:612)
● 54 year old woman with mucoepidermoid carcinoma of breast (Pathol Int 2006;56:549)
● Two low grade tumors (Arch Pathol Lab Med 1979;103:196)
● High grade and low grade tumors (Neoplasma 2007;54:168)

Micro description
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● Resembles salivary gland counterpart (Virchows Arch 2004;444:13)
● Mixture of neoplastic mucus-secreting, squamous and intermediate cells

Micro images
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In breast affected by burn scars

Salivary gland tumors: H&E and Alcian blue-PAS

Cytology description
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High grade tumors:
● Clusters of epithelial ductal cells with mixed glandular, squamous and intermediate cells
● May be scant intra- and extracellular mucin (Acta Cytol 2006;50:344)

Positive stains
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● Keratin, EMA and CEA
● Mucin is PAS+
● Have basal-like phenotype: strong and diffuse expression of CK5/6, p-cadherin, p63, EGFR (Appl Immunohistochem Mol Morphol 2012 Aug 29 [Epub ahead of print])

Negative stains
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● ER, PR and Her2 (Mod Pathol 2010;23:951)

Electron microscopy description
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● Intermediate cells are modified myoepithelial cells (Hum Pathol 1985;16:941)

Differential diagnosis
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● Metastatic salivary gland tumor (Acta Cytol 2002;46:377)

End of Breast malignant, males, children > Carcinoma subtypes > Mucoepidermoid carcinoma

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