Breast malignant, males, children
Other malignancies
Myeloid sarcoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 December 2016, last major update August 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: myeloid sarcoma breast
Cite this page: Myeloid sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantmyeloidsarcoma.html. Accessed December 12th, 2017.
Definition / general
  • See also leukemia - acute
  • Neoplasm of myeloid cells associated with acute myeloid leukemia (usually as relapse), myeloproliferative or myelodysplastic disorder
Terminology
  • Also called granulocytic sarcoma or chloroma
  • Not part of WHO breast classification
Epidemiology
  • Uncommon (< 100 cases reported)
  • Almost always women
  • Median age 52 years, range 31 - 73 years
Clinical features
Case reports
Treatment
Clinical images

Images hosted on PathOut server:

MRI, courtesy of Dr. Mark R. Wick

Gross images

Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick

Microscopic (histologic) description
  • Well to poorly differentiated to blastic tumor of immature and mature granulocytes or monocytes
  • Also immature eosinophilic precursors
  • Usually preserves ductal and lobular structures
  • No / minimal necrosis
  • Dissection of collagen by tumor cells is common (Chin Med J (Engl) 2008;121:1854)
Microscopic (histologic) images

Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick

Myeloperoxidase, courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Various images

Myeloperoxidase+ and CD43+

Cytology images

Images hosted on PathOut server:

Diff-Quik, courtesy of Dr. Mark R. Wick

Positive stains
Negative stains
Molecular / cytogenetics description
Differential diagnosis