Breast malignant, males, children
In situ carcinoma
Neuroendocrine DCIS

Author: Dina Kandil, M.D. (see Authors page)

Revised: 18 October 2016, last major update January 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Neuroendocrine DCIS

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Cite this page: Neuroendocrine DCIS. website. Accessed January 17th, 2019.
Definition / general
  • DCIS in which 50% or more cells express neuroendocrine markers (Histopathology 2008;53:288)
  • Regarded by some as DCIS with neuroendocrine features rather than a distinct type
Clinical features
Case reports
Microscopic (histologic) description
  • Solid lobular growth, neuroendocrine-like festoons and rosettes and prominent fibrovascular septa
  • Cells are polygonal, oval or spindled with abundant granular eosinophilic cytoplasm and bland ovoid nuclei
  • Accumulation of basophilic intracellular mucin
  • Often pagetoid spread and well developed vascular network
  • Variable stromal sclerosis or signet ring cells
  • Usually no necrosis
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #45


Focal Grimelius+ cells

Small cells with
dense, deeply stained
amphophilic cytoplasm
and uniform round nuclei

Cytology description
Cytology images

Images hosted on other servers:

Various images

Negative stains
Electron microscopy description
  • Dense core neurosecretory granules, larger mucigen granules
Differential diagnosis
  • Florid epithelial hyperplasia and papilloma: lacks the monomorphic cell population associated with DCIS, negative for neuroendocrine markers