Breast malignant, males, children
Carcinoma subtypes
Neuroendocrine carcinoma - large cell

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 October 2016, last major update August 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Neuroendocrine carcinoma [title] large cell

Cite this page: Neuroendocrine carcinoma - large cell. website. Accessed April 22nd, 2018.
Definition / general
  • Rare; poorly differentiated tumor composed of large, crowded clusters of cells with moderate / abundant cytoplasm, nuclei with vesicular or finely granular chromatin and frequent mitotic figures (18+ / 10 HPF)
  • Part of WHO classification
Case reports
  • Aggressive tumor requiring multimodal treatment
Clinical images

Images hosted on PathOut server:

Left lateral MRI, courtesy of Mark R. Wick, M.D.

Microscopic (histologic) description
  • Neuroendocrine differentiation morphologically and by immunohistochemistry; larger cell size than small cell carcinoma; frequent necrosis
Microscopic (histologic) images

Images hosted on PathOut server:

Left lateral, courtesy of Mark R. Wick, M.D.

Images hosted on other servers:

Nests of large tumor cells


Differential diagnosis