Breast malignant, males, children
Neuroendocrine carcinoma - large cell
Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 3 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Rare; poorly differentiated tumor composed of large, crowded clusters of cells with moderate / abundant cytoplasm, nuclei with vesicular or finely granular chromatin and frequent mitotic figures (18+/10 HPF)
● Part of WHO classification
● 27 year old woman (J Korean Med Sci 2008;23:1118)
● 63 year old woman with CK20+ tumor (Breast Cancer 2012;19:360)
● Aggressive tumor requiring multimodal treatment
● Neuroendocrine differentiation morphologically and by immunohistochemistry; larger cell size than small cell carcinoma; frequent necrosis
Nests of large tumor cells Chromogranin+
● Metastatic carcinoid tumor
● Small cell carcinoma: scant cytoplasm, small (diameter of three lymphocytes) nuclei with finely granular, evenly distributed chromatin and absent or inconspicuous nucleoli
End of Breast malignant, males, children > Carcinoma subtypes > Neuroendocrine carcinoma - large cell
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