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Table of Contents
Definition / general | Terminology | Case reports | Treatment | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Neuroendocrine carcinoma - large cell. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantneuroendocrinelargecell.html. Accessed July 14th, 2017.
Definition / general
- Rare; poorly differentiated tumor composed of large, crowded clusters of cells with moderate / abundant cytoplasm, nuclei with vesicular or finely granular chromatin and frequent mitotic figures (18+ / 10 HPF)
Terminology
- Part of WHO classification
Case reports
- 27 year old woman with primary large cell neuroendocrine carcinoma of the breast (J Korean Med Sci 2008;23:1118)
- 63 year old woman with cytokeratin 20-positive large cell neuroendocrine carcinoma of the breast (Breast Cancer 2012;19:360)
Treatment
- Aggressive tumor requiring multimodal treatment
Clinical images
Images hosted on PathOut server:
Left lateral MRI, courtesy of Mark R. Wick, M.D.
Microscopic (histologic) description
- Neuroendocrine differentiation morphologically and by immunohistochemistry; larger cell size than small cell carcinoma; frequent necrosis
Microscopic (histologic) images
Images hosted on PathOut server:
Left lateral, courtesy of Mark R. Wick, M.D.
Images hosted on other servers:
Nests of large tumor cells
Chromogranin+
Differential diagnosis
- Metastatic carcinoid tumor
- Small cell carcinoma: scant cytoplasm, small (diameter of three lymphocytes) nuclei with finely granular, evenly distributed chromatin and absent or inconspicuous nucleoli
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