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Breast malignant, males, children

Carcinoma subtypes

Neuroendocrine carcinoma - large cell


Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 3 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Definition
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● Rare; poorly differentiated tumor composed of large, crowded clusters of cells with moderate / abundant cytoplasm, nuclei with vesicular or finely granular chromatin and frequent mitotic figures (18+/10 HPF)

Terminology
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● Part of WHO classification

Case reports
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● 27 year old woman (J Korean Med Sci 2008;23:1118)
● 63 year old woman with CK20+ tumor (Breast Cancer 2012;19:360)

Treatment
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● Aggressive tumor requiring multimodal treatment

Micro description
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● Neuroendocrine differentiation morphologically and by immunohistochemistry; larger cell size than small cell carcinoma; frequent necrosis

Micro images
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Nests of large tumor cells   Chromogranin+

Differential diagnosis
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● Metastatic carcinoid tumor
Small cell carcinoma: scant cytoplasm, small (diameter of three lymphocytes) nuclei with finely granular, evenly distributed chromatin and absent or inconspicuous nucleoli

End of Breast malignant, males, children > Carcinoma subtypes > Neuroendocrine carcinoma - large cell


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