Breast malignant, males, children
Carcinoma subtypes
Neuroendocrine carcinoma - large cell

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 October 2016, last major update August 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Neuroendocrine carcinoma [title] large cell

Cite this page: Neuroendocrine carcinoma - large cell. website. Accessed April 23rd, 2017.
Definition / General
  • Rare; poorly differentiated tumor composed of large, crowded clusters of cells with moderate / abundant cytoplasm, nuclei with vesicular or finely granular chromatin and frequent mitotic figures (18+ / 10 HPF)
  • Part of WHO classification
Case Reports
  • Aggressive tumor requiring multimodal treatment
Clinical Images

Images hosted on PathOut server:

Left lateral MRI, courtesy of Mark R. Wick, M.D.

Micro Description
  • Neuroendocrine differentiation morphologically and by immunohistochemistry; larger cell size than small cell carcinoma; frequent necrosis
Micro Images

Images hosted on PathOut server:

Left lateral, courtesy of Mark R. Wick, M.D.

Images hosted on other servers:

Nests of large tumor cells


Differential Diagnosis