Breast malignant, males, children - Neuroendocrine carcinoma

Home Chapter Home Jobs Conferences Fellowships Books

Breast malignant, males, children

Carcinoma subtypes

Neuroendocrine carcinoma - large cell

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 3 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Definition
=========================================================================

● Rare; poorly differentiated tumor composed of large, crowded clusters of cells with moderate / abundant cytoplasm, nuclei with vesicular or finely granular chromatin and frequent mitotic figures (18+/10 HPF)

Terminology
=========================================================================

● Part of WHO classification

Case reports
=========================================================================

● 27 year old woman (J Korean Med Sci 2008;23:1118)
● 63 year old woman with CK20+ tumor (Breast Cancer 2012;19:360)

Treatment
=========================================================================

● Aggressive tumor requiring multimodal treatment

Micro description
=========================================================================

● Neuroendocrine differentiation morphologically and by immunohistochemistry; larger cell size than small cell carcinoma; frequent necrosis

Micro images
=========================================================================

Nests of large tumor cells Chromogranin+

Differential diagnosis
=========================================================================

● Metastatic carcinoid tumor
● Small cell carcinoma: scant cytoplasm, small (diameter of three lymphocytes) nuclei with finely granular, evenly distributed chromatin and absent or inconspicuous nucleoli

End of Breast malignant, males, children > Carcinoma subtypes > Neuroendocrine carcinoma - large cell

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).