Breast malignant, males, children - Neuroendocrine carcinoma

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Breast malignant, males, children

Carcinoma subtypes

Neuroendocrine carcinoma - solid type

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 29 October 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Definition
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● Neuroendocrine carcinomas with 50%+ neuroendocrine differentiation (based on chromogranin or synaptophysin staining), and densely cellular solid nests or trabeculae separated by a delicate fibrovascular stroma

Terminology
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● This is a distinct WHO diagnostic category

Clinical features
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● May have similar clinical features to breast carcinoma in general (Oncol Rep 2008;20:1369)

Case reports
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● 40 year old woman with solid neuroendocrine carcinoma of the breast (Breast Cancer 2007;14:250)
● 60 year old woman with breast tumor metastatic to renal cell carcinoma (Pathol Res Pract 2008;204:851)
● 63 year old woman with inflammatory carcinoma features (Ann Ital Chir 2012 May 31 [Epub ahead of print])
● Elderly man with argyrophilic neuroendocrine carcinoma of the breast (Ultrastruct Pathol 1993;17:115)
● Two cases with osteoclastic giant cells (Pathologica 2008;100:176)

Micro description
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● Densely cellular solid nests and trabeculae, or spindled, plasmacytoid or large cells, separated by a delicate fibrovascular stroma
● Rarely rosettes or other features resembling carcinoid tumor
● May originate from solid papillary DCIS or resemble alveolar subtype of lobular carcinoma

Micro images
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Various images

Various stains (fig a, b, g, h, i)

Other images: #1, #2, #3, #4

Cytology description
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● Dyscohesive polygonal cells with abundant cytoplasm, many containing eosinophilic granules located at one pole (Malays J Pathol 2008;30:57)

End of Breast malignant, males, children > Carcinoma subtypes > Neuroendocrine carcinoma - solid type

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