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Table of Contents
Definition / general | Terminology | Clinical features | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Cytology descriptionCite this page: Neuroendocrine carcinoma - solid type. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantneuroendocrinesolid.html. Accessed July 14th, 2017.
Definition / general
- Neuroendocrine carcinomas with 50%+ neuroendocrine differentiation (based on chromogranin or synaptophysin staining), and densely cellular solid nests or trabeculae separated by a delicate fibrovascular stroma
Terminology
- This is a distinct WHO diagnostic category
Clinical features
- May have similar clinical features to breast carcinoma in general (Oncol Rep 2008;20:1369)
Case reports
- 40 year old woman with solid neuroendocrine carcinoma of the breast (Breast Cancer 2007;14:250)
- 60 year old woman with breast tumor metastatic to renal cell carcinoma (Pathol Res Pract 2008;204:851)
- 63 year old woman with inflammatory carcinoma features (Ann Ital Chir 2012 May 31 [Epub ahead of print])
- Elderly man with argyrophilic neuroendocrine carcinoma of the breast (Ultrastruct Pathol 1993;17:115)
- Two cases with osteoclastic giant cells (Pathologica 2008;100:176)
Microscopic (histologic) description
- Densely cellular solid nests and trabeculae, or spindled, plasmacytoid or large cells, separated by a delicate fibrovascular stroma
- Rarely rosettes or other features resembling carcinoid tumor
- May originate from solid papillary DCIS or resemble alveolar subtype of lobular carcinoma
Microscopic (histologic) images
Images hosted on Nature servers:
Various stains (fig a, b, g, h, i)
Images hosted on other servers:
Various images
Cytology description
- Dyscohesive polygonal cells with abundant cytoplasm, many containing eosinophilic granules located at one pole (Malays J Pathol 2008;30:57)
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