Neuroendocrine carcinoma

Topic Completed: 1 August 2012

Minor changes: 21 June 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Neuroendocrine carcinoma solid type

Monika Roychowdhury, M.D.
Page views in 2019: 1,352
Page views in 2020 to date: 786
Cite this page: Roychowdhury M. Solid. website. Accessed August 7th, 2020.
Definition / general
  • Neuroendocrine carcinomas with 50%+ neuroendocrine differentiation (based on chromogranin or synaptophysin staining), and densely cellular solid nests or trabeculae separated by a delicate fibrovascular stroma
  • This is a distinct WHO diagnostic category
Clinical features
Case reports
Microscopic (histologic) description
  • Densely cellular solid nests and trabeculae, or spindled, plasmacytoid or large cells, separated by a delicate fibrovascular stroma
  • Rarely rosettes or other features resembling carcinoid tumor
  • May originate from solid papillary DCIS or resemble alveolar subtype of lobular carcinoma
Microscopic (histologic) images

Images hosted on other servers:

Various stains (fig a, b, g, h, i)

Various images

Cytology description
  • Dyscohesive polygonal cells with abundant cytoplasm, many containing eosinophilic granules located at one pole (Malays J Pathol 2008;30:57)
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