Breast malignant, males, children
Carcinoma subtypes
Neuroendocrine carcinoma - solid type

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 October 2016, last major update August 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Neuroendocrine carcinoma solid type

Cite this page: Neuroendocrine carcinoma - solid type. website. Accessed August 15th, 2018.
Definition / general
  • Neuroendocrine carcinomas with 50%+ neuroendocrine differentiation (based on chromogranin or synaptophysin staining), and densely cellular solid nests or trabeculae separated by a delicate fibrovascular stroma
  • This is a distinct WHO diagnostic category
Clinical features
Case reports
Microscopic (histologic) description
  • Densely cellular solid nests and trabeculae, or spindled, plasmacytoid or large cells, separated by a delicate fibrovascular stroma
  • Rarely rosettes or other features resembling carcinoid tumor
  • May originate from solid papillary DCIS or resemble alveolar subtype of lobular carcinoma
Microscopic (histologic) images

Images hosted on Nature servers:

Various stains (fig a, b, g, h, i)

Images hosted on other servers:

Various images

Cytology description
  • Dyscohesive polygonal cells with abundant cytoplasm, many containing eosinophilic granules located at one pole (Malays J Pathol 2008;30:57)