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Breast malignant, males, children

Carcinoma subtypes

Oncocytic carcinoma


Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 3 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Definition
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● Composed of 70%+ oncocytic cells
● Also called malignant oncocytoma

Epidemiology
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● Very rare (< 20 cases reported), usually age 60+ years

Prognostic factors
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● Usually high grade (grade 3)

Case reports
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● 46 year old woman (Zentralbl Allg Pathol 1987;133:279)
● 70 year old woman (Zentralbl Allg Pathol 1989;135:357)
● 76 year old man (Arch Pathol Lab Med 1989;113:1396)

Micro description
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● Well-circumscribed, abundant granular eosinophilic cytoplasm and low grade nuclei with conspicuous nucleoli (Am J Surg Pathol 1998;22:221)
● Similar to apocrine carcinoma on H&E, but different staining pattern
● No / rare mitotic figures

Micro images
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Salivary gland oncocytic carcinoma

Virtual slides
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Virtual slide

Positive stains
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● Anti-mitochondrial antibody, HER2 (Hum Pathol 2011;42:166)

Negative stains
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● GCDFP-15

Electron microscopy description
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● Numerous mitochondria dispersed throughout cell, occupying 60%+ of cytoplasm

Differential diagnosis
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Apocrine carcinoma: GCDFP-15+, negative for antimitochondrial antibody

Additional references
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Stanford University

End of Breast malignant, males, children > Carcinoma subtypes > Oncocytic carcinoma


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