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Breast malignant, males, children

Other malignancies


Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 17 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Neoplasm of plasma cells, either primary to breast or secondary (most cases) to a systemic process or another plasmacytoma


● Not part of WHO breast classification

Clinical features

● Rare
● May progress to multiple myeloma after years of remission
● Frozen section diagnoses are often incorrect - resembles lobular or poorly differentiated tumor, but with a grossly well circumscribed appearance

Case reports

● 27 year old woman with coexisting ductal carcinoma (World J Surg Oncol 2009;7:43)
● 37 year old woman with only breast involvement (Arch Pathol Lab Med 2001;125:1078)
● 70 year old woman with recurrence of mediastinal disease in bilateral breasts (World J Surg Oncol 2004;2:29)
● 78 year old man with breast and axillary nodal involvement (Clin Breast Cancer 2006;7:81)
● Patient with disease free survival of 9+ years (Arch Pathol Lab Med 1984;108:676)

Clinical images

Well-defined mass with irregular borders

Micro description

● Immature and mature plasma cells with nuclear pleomorphism
● Also binucleated and multinucleated forms, mitotic figures and necrosis

Micro images

Plasma cells, some binucleated,   Nuclear pleomorphism, binucleated and
surrounding benign lobules     multinucleated plasma cells with enlarged nucleoli

Tumor in HIV+ man

Plasma cells (long arrows),      Dense infiltrate of plasma cells
Russell bodies (short arrow)    and lymphocytes (AFIP)
and lymphocytes

With ductal carcinoma       Her-2 negtive

Plasma cells are IgA+        Monoclonal lambda staining
and kappa light chain+

Kappa staining            Diffuse Ki-67 nuclear staining

Cytology description

● Dispersed population of plasmacytoid cells at various stages of maturation (Acta Cytol 2003;47:1107)
● Mature plasma cells have an eccentric nucleus and abundant deep basophilic cytoplasm with a paranuclear halo
● Plasmablasts (immature plasma cells) have a prominent eccentric nucleus with a single large nucleolus and abundant deep basophilic cytoplasm with no paranuclear halo
● Also binucleate and multinucleate forms (Acta Cytol 1997;41:364)

Differential diagnosis

Plasma cell mastitis: no light chain restriction
MALT lymphoma

End of Breast malignant, males, children > Other malignancies > Plasmacytoma

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