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Breast malignant, males, children

Breast cancer

Prognostic factors - Fibrotic focus

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 19 December 2012, last major update February 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Mixture of fibroblasts and collagen fibers that may occupy almost the entire center of an invasive ductal carcinoma, replacing the necrotic central area (see also central acellular subtype)
● May be due to intratumoral hypoxia (Histopathology 2007;51:440), leading to clonal heterogeneity of tumor cells (Mod Pathol 2001;14:325)
● Invasive ductal carcinomas with fibrotic focus have poorer survival than those without (Mod Pathol 2002;15:502, Jpn J Cancer Res 1997;88:590)
● Associated with basal-like subtype, activated wound-healing signature and a poor prognosis 76-gene signature (Clin Cancer Res 2008;14:2944)
● Fibrotic focus diameter greater than 8 mm and fibrotic focus fibrosis grade 1 predict distant organ metastasis and bone metastasis in patients with invasive ductal carcinoma who did not receive adjuvant therapy (Hum Pathol 2008;39:681)

Micro images


Various images

Low power

MIB1+ fibroblasts

Figure 3

End of Breast malignant, males, children > Breast cancer > Prognostic factors - Fibrotic focus

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