Breast malignant, males, children
Breast cancer
Prognostic factors - Fibrotic focus

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 27 September 2018, last major update February 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Fibrotic focus [title]

Cite this page: Roychowdhury, M. Prognostic factors - Fibrotic focus. website. Accessed November 14th, 2018.
Definition / general
  • Mixture of fibroblasts and collagen fibers that may occupy almost the entire center of an invasive ductal carcinoma, replacing the necrotic central area (see also central acellular subtype)
  • May be due to intratumoral hypoxia (Histopathology 2007;51:440), leading to clonal heterogeneity of tumor cells (Mod Pathol 2001;14:325)
  • Invasive ductal carcinomas with fibrotic focus have poorer survival than those without (Mod Pathol 2002;15:502, Jpn J Cancer Res 1997;88:590)
  • Associated with basal-like subtype, activated wound healing signature and a poor prognosis 76-gene signature (Clin Cancer Res 2008;14:2944)
  • Fibrotic focus diameter greater than 8 mm and fibrotic focus fibrosis grade 1 predict distant organ metastasis and bone metastasis in patients with invasive ductal carcinoma who did not receive adjuvant therapy (Hum Pathol 2008;39:681)
Microscopic (histologic) images

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Various images

Fibrotic focus