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Breast malignant, males, children

Sarcoma

Sarcoma NOS


Reviewer: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 21 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● A diagnosis of exclusion
● Extensive tumor sampling and immunostaining are required before making this diagnosis

Terminology
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● Not part of WHO breast classification

Micro description
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● Spindle cells with markedly pleomorphic nuclei and abundant mitotic figures (Am J Surg Pathol 2006;30:450)
● By definition, no evidence of carcinoma or a specific type of sarcomatous differentiation

Positive stains
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● CD10, vimentin
● EGFR (often)

Negative stains
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● Keratin, CD34, desmin, h-caldesmon

Differential diagnosis
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Sarcomatoid metaplastic carcinoma: keratin+
Stromal sarcoma: CD34+, no severe atypia

End of Breast malignant, males, children > Sarcoma > Sarcoma NOS


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