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Breast malignant, males, children

Sarcoma

General


Reviewer: Monika Roychowdhury, M.D (see Reviewers page)
Revised: 24 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Epidemiology
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● Rare, < 0.1% of breast malignancies
● Median age 45-55 years
● Sarcomas rarely occur post-radiation therapy for breast cancer (Cancer 2005;104:856)
● Most common subtype is angiosarcoma (40%)

Treatment and prognosis
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● Treatment is similar as other sarcomas - excision with negative margins (J Clin Oncol 2003;21:2583)
● Axillary dissection not indicated
● 5 year overall survival is 67% (83% for tumors <5 cm and 42% for tumors >5 cm (Am J Surg 2008;196:559, Br J Cancer 2004;91:237)
● Angiosarcoma has worst prognosis (Radiother Oncol 2007;85:355, J Clin Oncol 2003;21:2583)

Gross description
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● Median size 4 cm

Micro description
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● Low grade: 0-5 mitotic figures/10 HPF and low grade nuclei
● High grade: 5+ mitotic figures/HPF and marked nuclear atypia or 6+ mitotic figures/HPF and moderate nuclear atypia

End of Breast malignant, males, children > Sarcoma > General


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