Advertisement
Advertisement
Table of Contents
Definition / general | Clinical features | Case reports | Treatment | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Cytology images | Positive stains | Negative stains | Electron microscopy description | Differential diagnosisCite this page: Squamous cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantscc.html. Accessed July 14th, 2017.
Definition / general
- Primary breast carcinoma composed entirely of metaplastic squamous cells with variable keratin or spindle cells
Clinical features
- Very rare (< 0.2% of breast primaries) if exclude cutaneous tumors, squamous component of phyllodes tumors and squamous-like areas of medullary carcinoma (Hum Pathol 1984;15:526)
- Aggressive and often refractory to treatment (Eur J Obstet Gynecol Reprod Biol 2008;137:222, J Clin Oncol 2005;23:7827)
Case reports
- 32 year old woman with primary squamous cell carcinoma of the breast during lactation (Jpn J Clin Oncol 2000;30:279)
- 55 year old woman with primary squamous cell carcinoma of the breast (Fukushima J Med Sci 2005;51:105)
- 61 year old woman with breast abscess as the initial manifestation of primary pure squamous cell carcinoma (Breast Dis 2011;33:125)
- 71 year old woman with squamous cell carcinoma of the breast in the form of an intracystic tumor (Breast Cancer 2007;14:109)
- 72 year old woman with squamous cell carcinoma of the breast (World J Surg Oncol 2008;6:135)
- Squamous cell carcinoma of the breast (Arch Pathol Lab Med 1984;108:893)
- Pure squamous cell carcinoma of the breast presenting as a pyogenic abscess (Clin Breast Cancer 2007;7:713)
Treatment
- Possibly cisplatin based chemotherapy (Clin Breast Cancer 2009;9:187)
Gross description
- May have central cyst with keratin
Gross images
Images hosted on PathOut server:
Partially cystic tumor (arrows at margins, AFIP)
Images hosted on other servers:
Circumscribed and hemorrhagic tumor
Microscopic (histologic) description
- Tumor composed entirely of malignant squamous cells with variable keratinization and spindle cells
- Bland squamous cells may line cystic spaces
- May represent squamous metaplasia in ductal carcinoma
- May have prominent myxoid stroma
Microscopic (histologic) images
Images hosted on PathOut server:
Contributed by Dr. Mark R. Wick:
Invasive
Primary invasive
Primary
AFIP images:
Poorly differentiated tumor with acantholysis and keratin pearl
Spaces between tumor cells may be mistaken for vessels
Squamous cell carcinoma
with transition to metaplastic
spindle cells and early
acantholytic changes
Images hosted on other servers:
Keratinizing tumor
Nonkeratinizing tumor
Nonkeratinizing tumor
Cytology description
- Squamous cells, isolated and in aggregates and at various stages of maturation (Diagn Cytopathol 2007;35:429)
Cytology images
Images hosted on other servers:
Polygonal tumor cells with abundant eosinophilic cytoplasm and nucleus hyperchromasia
Positive stains
- EGFR (85%, Int J Surg Pathol 2005;13:319), 34betaE12, CK 5 / 6 (75%), p63 (70%)
- High Ki67 (Anticancer Res 2007;27:547)
Electron microscopy description
- May have glandular features ultrastructurally (Arch Pathol Lab Med 1980;104:130)
Differential diagnosis
- Post-traumatic lobular squamous metaplasia (Mod Pathol 1988;1:385)
- Other squamous metaplasia (Eur J Cancer Care (Engl) 2009;18:650)
- Metastasis to breast: see Anticancer Res 2008;28:1299
Advertisement
