Breast malignant, males, children
Carcinoma subtypes
Squamous cell carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 2 January 2017, last major update August 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: squamous cell carcinoma breast
Cite this page: Squamous cell carcinoma. website. Accessed August 15th, 2018.
Definition / general
  • Primary breast carcinoma composed entirely of metaplastic squamous cells with variable keratin or spindle cells
Clinical features
Case reports
Gross description
  • May have central cyst with keratin
Gross images

Images hosted on PathOut server:

Partially cystic tumor (arrows at margins, AFIP)

Images hosted on other servers:

Circumscribed and hemorrhagic tumor

Microscopic (histologic) description
  • Tumor composed entirely of malignant squamous cells with variable keratinization and spindle cells
  • Bland squamous cells may line cystic spaces
  • May represent squamous metaplasia in ductal carcinoma
  • May have prominent myxoid stroma
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick:


Primary invasive


AFIP images:

Poorly differentiated tumor with acantholysis and keratin pearl

Spaces between tumor cells may be mistaken for vessels

Squamous cell carcinoma
with transition to metaplastic
spindle cells and early
acantholytic changes

Images hosted on other servers:

Keratinizing tumor

Nonkeratinizing tumor

Nonkeratinizing tumor

Cytology description
Cytology images

Images hosted on other servers:

Polygonal tumor cells with abundant eosinophilic cytoplasm and nucleus hyperchromasia

Positive stains
Negative stains
Electron microscopy description
Differential diagnosis